{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:28:40Z","timestamp":1780082920259,"version":"3.54.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Functional constipation (FC) is a common problem in childhood and the first\u2010line therapy is macrogol. The role of FC in the onset of inflammatory bowel disease (IBD) is poorly understood. Our main aim was to investigate the prevalence of FC in children before the diagnosis of IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional observational study in pediatric IBD\u2010patients. We collected data on demographics, clinical and endoscopic characteristics at IBD diagnosis, and on the presence of FC and its treatment before IBD diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 238 children with IBD, 104 (44%) with Crohn disease (CD), 130 (56%) with ulcerative colitis (UC) and 4 (0.016%) with IBD Unclassified (IBD\u2010U) were enrolled. The mean age was 174\u2009\u00b1\u200947 months, 56% were male. Forty\u2010seven out of 238 (19.7%) had a FC history before the IBD diagnosis and 31 out of these 47 patients (65%) received macrogol therapy. In the FC group, we found a delay in the diagnosis of IBD compared to the group with no FC [median (interquartile range [IQR]): 5 months (2.5\u20139.5) and 2 months (0\u20134), respectively, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001]. The difference in terms of endoscopic localization was statistically significant in UC patients presenting FC (<jats:italic>p<\/jats:italic>\u2009=\u20090.026) with a prevalence of proctitis and left side colitis (30% and 15%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion our study highlighted a prevalence of constipation in pediatric IBD patients at diagnosis of 19.7%, which must be taken into account to avoid diagnostic delay and which is associated with limited extent of disease in UC pediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70005","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T02:41:16Z","timestamp":1739328076000},"page":"799-806","source":"Crossref","is-referenced-by-count":5,"title":["The prevalence of constipation in children with new diagnosis of inflammatory bowel disease: A retrospective study"],"prefix":"10.1002","volume":"80","author":[{"given":"Sabrina","family":"Cenni","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colucci","sequence":"additional","affiliation":[{"name":"Department of Woman Child and General and Specialist Surgery, University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Salomone","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics, University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pacella","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \u201cFederico II\u201d Naples 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