{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:32:02Z","timestamp":1786653122766,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The Eosinophilic Esophagitis Histology Scoring System (EoEHSS) is useful for diagnosing and characterizing eosinophilic esophagitis (EoE). A limitation of the EoEHSS is that lamina propria fibrosis scores are infrequently determined due to challenges in sampling lamina propria. Low distensibility index (DI) measured by endoluminal functional lumen imaging probe (EndoFLIP) is associated with fibrostenotic severity in pediatric patients with EoE. We investigated the correlation between DI and the EoEHSS to understand whether EndoFLIP could be a useful complementary tool for evaluating EoE\u2010associated remodeling in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical records of patients &lt;21 years of age who underwent an esophagogastroduodenoscopy (EGD) with biopsy and EndoFLIP between October 2017 and July 2023 with histologic diagnoses of normal\/reactive, reflux, or EoE. EoEHSS scores and luminal parameters were compared between groups. DI measured at 30\u2009mL inflation was compared with EoEHSS scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010six EGDs with biopsy and EndoFLIP were performed on 112 patients. There were 80 normal\/reactive, 32 reflux, and 14 EoE biopsies. At 30\u2009mL inflation, DI was lowest in the EoE group (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). DI at 30\u2009mL inflation negatively correlated with the EoEHSS overall grade score, as well as grade and stage scores for eosinophil abscesses, eosinophil surface layering, dilated intercellular spaces, and basal zone hyperplasia (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). DI at 30\u2009mL inflation also negatively correlated with the eosinophilic inflammation stage score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DI measured by EndoFLIP at 30\u2009mL inflation shows a negative correlation with composite EoEHSS scores and subscores, suggestive of remodeling. EndoFLIP may complement the EoEHSS in evaluating EoE\u2010associated esophageal remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70013","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:57:56Z","timestamp":1739771876000},"page":"824-831","source":"Crossref","is-referenced-by-count":16,"title":["EndoFLIP distensibility index correlates with histologic findings in children with eosinophilic esophagitis"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-0083","authenticated-orcid":false,"given":"Erik","family":"Almazan","sequence":"first","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom Z.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4937-1126","authenticated-orcid":false,"given":"Brenna","family":"Hohl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's National Hospital Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-5662","authenticated-orcid":false,"given":"Brett J.","family":"Hoskins","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Indiana University School of Medicine, Riley Hospital for Children at IU Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1224-3304","authenticated-orcid":false,"given":"Jacqueline E.","family":"Birkness\u2010Gartman","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-6204","authenticated-orcid":false,"given":"Kenneth","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15231"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.065"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1502863"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0770-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"1","article-title":"Newly developed and validated Eosinophilic Esophagitis Histology Scoring System and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring","volume":"30","author":"Collins MH","year":"2017","journal-title":"Dis 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