{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:25:09Z","timestamp":1790270709679,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Inflammatory bowel disease (IBD) is an immune\u2010mediated, chronic, remitting, and relapsing disease. Calprotectin, used in monitoring the disease activity, is expressed from neutrophilic granulocytes during inflammation. Neutrophil gelatinase\u2010associated lipocalin (NGAL) is strongly expressed in both granulocytes and the intestinal epithelial cell layer. The aim of the study was to compare fecal NGAL (FNGAL) with fecal calprotectin (FCAL) in children with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four children with IBD and 22 healthy children were included in the study. The patients were divided into two groups, patients with active disease and remission group. Clinical and demographic characteristics, disease activity scores, and serum and fecal markers of the patients were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 13.2\u2009\u00b1\u20093.4 years (range 6\u201317 years) and male\/female: 0.62. FNGAL levels of patients with active disease were higher than those in the remission group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A statistically significant positive correlation was observed between Pediatric Ulcerative Colitis Activity Index scores and white blood cell count, platelets, neutrophil\u2010to\u2010albumin ratio (NAR), erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP), and FNGAL. There was a positive correlation between Pediatric Crohn's Disease Activity Index scores and platelets, NAR, ESR, CRP, and FNGAL, whereas there was a statistically significantly negative correlation with activity scores and albumin. While FNGAL had 95.5% sensitivity and 81.8% specificity, FCAL had 86.7% sensitivity and 85.7% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FNGAL levels were found to be high and sensitive in determining disease activity in our patients with IBD, suggesting that it may be a valuable biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70015","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T07:11:21Z","timestamp":1739949081000},"page":"792-798","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of fecal neutrophil gelatinase\u2010associated lipocalin levels in childhood inflammatory bowel disease"],"prefix":"10.1002","volume":"80","author":[{"given":"Aysenur","family":"Kardas Yildiz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sisli Hamidiye Etfal Training and Research Hospital University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4854-507X","authenticated-orcid":false,"given":"Nafiye","family":"Urganci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Sisli Hamidiye Etfal Training and Research Hospital University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Merve","family":"Usta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Sisli Hamidiye Etfal Training and Research Hospital University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.058"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182810066"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3369"},{"issue":"55","key":"e_1_2_7_7_1","first-page":"xv","article-title":"Faecal calprotectin testing for differentiating amongst inflammatory and non\u2010inflammatory bowel diseases: systematic review and economic evaluation","volume":"17","author":"Waugh N","year":"2013","journal-title":"Health Technol Assess 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