{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:20:55Z","timestamp":1773364855569,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess the evolution of nutritional status, parenteral nutrition (PN) composition, and PN dependence index (PNDI) in children under 2 years old with intestinal failure (IF) and malnutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort included patients admitted between November 1, 2016, and August 31, 2021, with IF, age \u226424 months, and weight\u2010for\u2010age (Wt\/A) &lt;\u22122 standard deviation with a follow\u2010up of 12 months. Data collected included demographic, anthropometric, biochemical, and nutritional information. The PNDI was compared between enteral autonomy (EA) and nonenteral autonomy (non\u2010EA) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (16 males, 53.33%) were included, and short bowel syndrome (SBS) was the leading cause of IF (<jats:italic>n<\/jats:italic>\u2009=\u200927, 90%). The mean age at admission was 7.23\u2009\u00b1\u20093.90 months, and 36.66% of the patients had a conjugated bilirubin (CB) level &gt;2\u2009mg\/dL; 87% had a Wt\/A <jats:italic>z<\/jats:italic>\u2010score &lt;\u22123 and 90% had a height\u2010for\u2010age (Ht\/A) <jats:italic>z<\/jats:italic>\u2010score &lt;\u22123. At 5 months, the mean Wt\/A <jats:italic>z<\/jats:italic>\u2010score improved to \u22121.82. At admission, median protein, lipid, and glucose intake on PN were 3, 1.6, and 17.27\u2009g\/kg\/day, respectively. In the PNDI analysis, the EA group had a mean index of 141% versus 158% for the non\u2010EA group at admission, with no statistical differences. From the sixth month onward, the EA group showed a significantly lower PNDI (50% vs. 108% for non\u2010EA patients; <jats:italic>p<\/jats:italic>\u2009=\u20090.032). Both groups demonstrated adequate nutritional recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adequate multidisciplinary care can reverse severe malnutrition, and the PNDI may be a predictor of EA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70018","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T04:29:58Z","timestamp":1739852998000},"page":"880-888","source":"Crossref","is-referenced-by-count":1,"title":["Nutritional management and outcomes of malnourished children under 2 years with intestinal failure"],"prefix":"10.1002","volume":"80","author":[{"given":"Estela Cristina","family":"Pavanelli","sequence":"first","affiliation":[{"name":"Intestinal Rehabilitation and Transplant Center Hospital Sirio\u2010Libanes Sao Paulo Sao Paulo Brazil"},{"name":"Hospital Municipal Infantil Menino Jesus Sao Paulo Sao Paulo Brazil"},{"name":"Institute for Advanced Intestinal Rehabilitation Sao Paulo Sao Paulo 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