{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:41:25Z","timestamp":1789753285920,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In a subgroup of children with refractory constipation, colonic function investigations, such as colonic transit scintigraphy (CS) and colonic manometry (CM), are used to define the underlying pathophysiologic mechanisms. There are limited studies comparing colonic transit and contractile function. We aimed to correlate CS and CM and assess whether specific manometric patterns might predict the luminal transit findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with refractory constipation undergoing both CS and CM between 2012 and 2022 at two Tertiary Pediatric Gastroenterology Services were retrospectively reviewed. For CS, the geometric center (GC) was used to quantify the transit across the different colonic segments and studies were categorized into normal transit, recto\u2010sigmoid hold\u2010up, and slow transit. Contractile patterns from CM were classified into equivalent regional subtypes as normal, distal colonic dysmotility and pan\u2010colonic dysmotility, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients (59% male, median age: 10.94 years) were included. No significant agreement in the subtype of constipation was found between CS and CM (<jats:italic>K<\/jats:italic>\u2009=\u20090.224, <jats:italic>p<\/jats:italic>\u2009=\u20090.070). However, a strong correlation was observed between the numeric score of the GC at 6\u2009h and the amplitude of bisacodyl\u2010induced high amplitude propagating contractions (HAPCs) in the rectosigmoid (<jats:italic>r<\/jats:italic>\u2009=\u20090.761, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Moreover, a higher percentage of radiotracers in the ascending colon at 24\u2009h was related to a higher number of bisacodyl\u2010induced HAPCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Scintigraphic GC at 6\u2009h showed a substantial correlation with parameters from CM in the rectosigmoid colon, implicating the potential role of this colonic region as a gatekeeper for colonic luminal transit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70025","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:49:04Z","timestamp":1741697344000},"page":"909-919","source":"Crossref","is-referenced-by-count":1,"title":["Colonic transit studies and colonic manometry in pediatric constipation"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-4973","authenticated-orcid":false,"given":"Atchariya","family":"Chanpong","sequence":"first","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Gastroenterology Department Great Ormond Street Hospital for Children London UK"},{"name":"Department of Pediatrics, Division of Gastroenterology and Hepatology, Faculty of Medicine Prince of Songkla University Songkhla Thailand"},{"name":"Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Morris","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Radiology Great Ormond Street Hospital for Children London UK"},{"name":"Clinical Physics, Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Di Chio","sequence":"additional","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Gastroenterology Department Great Ormond Street Hospital for Children London UK"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), Hospital for Sick Children, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Nita","sequence":"additional","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Gastroenterology Department Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Lindley","sequence":"additional","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Gastroenterology Department Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rybak","sequence":"additional","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Gastroenterology Department Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Medical Imaging and Nuclear Medicine, Queensland Children's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Biassoni","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Radiology Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-9951","authenticated-orcid":false,"given":"Nikhil","family":"Thapar","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital Brisbane Queensland Australia"},{"name":"Faculty of Medicine, Centre for Childhood Nutrition Research University of Queensland Brisbane Queensland Australia"},{"name":"Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-0508","authenticated-orcid":false,"given":"Osvaldo","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Gastroenterology Department Great Ormond Street Hospital for Children London UK"},{"name":"Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126982"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.129973"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.11.029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91092-I"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12295"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002504"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003429"},{"key":"e_1_2_8_9_1","first-page":"1395","article-title":"Gastrointestinal motility, part 2: small\u2010bowel and colon transit","volume":"56","author":"Maurer AH","year":"2015","journal-title":"J Nucl Med"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12876"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00386.2019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2387-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31829e0bdd"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2020.23.2.137"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12760"},{"key":"e_1_2_8_16_1","first-page":"890","article-title":"Periodic rectal motor activity: the intrinsic colonic gatekeeper?","volume":"91","author":"Rao SS","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00194.2001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00359.2001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12408"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91098-O"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(49)90463-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15945-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0167-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01965.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22941"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14759"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.2.G329"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14285"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:04:41Z","timestamp":1756969481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/jpn3.70025"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70025","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]}}}