{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:54:50Z","timestamp":1783382090235,"version":"3.54.6"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with nutritional risks. This study describes vitamin D status and intake in children undergoing HSCT and compares results to healthy children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective observational study, vitamin 25(OH)D and 1,25(OH)<jats:sub>2<\/jats:sub>D were assessed at hospital admission before HSCT (baseline), at 3\u2010month\u00a0and 1\u2010year post\u2010transplant. Vitamin D deficiency was defined as 25(OH)D\u2009&lt;\u200950 nmol\/L. A 4\u2010day diet record assessed vitamin D intake at 3\u2010months and 1\u2010year. Healthy children were assessed once.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight HSCT patients (mean age: 10.3\u2010years, standard deviation [SD]: 4.0) and 50 healthy children (mean age: 10.0\u2010years, SD: 3.6) were included. Vitamin D deficiency was more prevalent in patients at baseline (36%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 3\u2010months (24%, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) but not at 1\u2010year (14%, <jats:italic>p<\/jats:italic>\u2009=\u20090.084) than in healthy children (2%). Median 1,25(OH)<jats:sub>2<\/jats:sub>D was significantly lower than in healthy children at the two first visits (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but not at 1\u2010year (<jats:italic>p<\/jats:italic>\u2009=\u20090.198). Median vitamin D provision was higher at 3\u2010months (18.1\u2009\u00b5g\/day) and 1\u2010year (25\u2009\u00b5g\/day) compared to healthy children (5.3\u2009\u00b5g\/day, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children undergoing HSCT were at a high risk of vitamin D deficiency at baseline and 3\u2010month post\u2010transplant, but not at 1\u2010year compared to healthy children. Vitamin D intake was higher after transplantation than in healthy children. These findings indicate that vitamin D requirements are elevated in HSCT patients, emphasizing the need for monitoring and adequate supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Clinical Trials AEV2017\/1. 2016\/391\/REK s\u00f8r\u2010\u00f8st B.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70028","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T21:40:46Z","timestamp":1742852446000},"page":"1007-1017","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D status in children undergoing allogeneic hematopoietic stem cell transplantation: A prospective exploratory study"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-0672","authenticated-orcid":false,"given":"Janne Anita","family":"Kvammen","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine Oslo University Hospital Oslo Norway"},{"name":"Department of Nutrition Institute 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