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The team developed 12 vital questions to address gaps in the current understanding and practice of using BTFs, then performed a comprehensive search of literature published between 2000 and 2023 using PubMed, MEDLINE, Embase databases, and an individual search of references. There was a scarcity of well\u2010designed randomized clinical trials, and most of the studies were prospective or retrospective observational reports from heterogeneous patient demographics, varieties of BTFs, and medical conditions. Use of BTFs was associated with improved outcomes, including higher satisfaction, reduced gastroesophageal reflux, retching, gagging, constipation, frequency of hospitalization for respiratory disease, and greater diversity of the gut microbiome. However, homemade and commercially manufactured BTFs varied in nutrient composition and physical properties, such as viscosity, which posed challenges related to ease of administration and comparison of clinical outcomes. Therefore, whereas the use of BTFs as an alternative to standard commercial formulas has become increasingly popular, further evidence is warranted to provide guidelines on best practices for usage, monitoring, and comparing clinical outcomes. Pediatric dietitians and clinician practitioners must regularly monitor children receiving BTFs to ensure nutritional adequacy, optimize safe and effective delivery, and promote optimal growth. The team proposed future directions regarding best practices for using BTFs, primarily related to clinical application and nutritional outcomes in children and adolescents.<\/jats:p>","DOI":"10.1002\/jpn3.70048","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T01:59:04Z","timestamp":1746496744000},"page":"376-386","source":"Crossref","is-referenced-by-count":5,"title":["State\u2010of\u2010the\u2010art review of blenderized diets\u2014Status and future directions"],"prefix":"10.1002","volume":"81","author":[{"given":"Sharon","family":"Weston","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushree","family":"Algotar","sequence":"additional","affiliation":[{"name":"C.S. 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