{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:52:08Z","timestamp":1790837528527,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Intestinal ultrasound (IUS) is a noninvasive tool for detecting and monitoring disease activity in children with inflammatory bowel disease (IBD). Remission values for bowel wall thickness (BWT) are extrapolated from adult data. We aimed to define normal BWT in children with IBD in sustained deep remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter, retrospective pediatric IUS database including children with IBD, without a history of surgery or complications, who underwent IUS after achieving sustained deep remission, defined as the absence of ulcerations on ileocolonoscopy and\/or transmural healing on magnetic resonance enterography and steroid\u2010free clinical remission for \u22656 months. Univariate and multivariable analyses were performed using mixed\u2010effect modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010eight children (40 [41%] female; 64 [5%] Crohn's disease [CD]: 29 (30%) ulcerative colitis [UC]: 5 (5%) IBD\u2010unspecified), median age 15.2 [13.8\u201316.8] years), and 484 bowel segments were included. Median BWT was 1.4 (1.1\u20131.6) mm, with no difference in BWT between bowel segments (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.28). In multivariable analysis, a positive association remained between BWT and weight (univariate\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.004 [95% confidence interval, CI\u2009=\u20090.001\u20130.007],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016, multivariate\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.006 [95% CI\u2009=\u20090.001\u20130.011],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). A negative association remained between BWT and disease duration (unadjusted\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.024 [95% CI\u2009=\u2009\u22120.047 to \u22120.001]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046, adjusted\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.028 [95% CI\u2009=\u2009\u22120.052 to \u22120.003],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Previously inflamed BWT for children with IBD in sustained deep remission was less than 2.5\u2009mm, which is less than 3\u2009mm in adults, and unaffected by age, sex, and bowel segment in this population. BWT may be affected by weight and disease duration. These findings are crucial to the standardized assessment of transmural healing in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70049","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:14:49Z","timestamp":1745896489000},"page":"53-61","source":"Crossref","is-referenced-by-count":19,"title":["Defining normal bowel wall thickness in children with inflammatory bowel disease in deep remission: A multicenter study on behalf of the pediatric committee of the International Bowel Ultrasound Group (IBUS)"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-5341","authenticated-orcid":false,"given":"Amelia","family":"Kellar","sequence":"first","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology and Nutrition, Comer Children's Hospital at the University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallory","family":"Chavannes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Department of Pediatrics Keck School of Medicine of the University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien Q.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illya","family":"Aronskyy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, Susan and Leonard Feinstein Inflammatory Bowel Disease Center Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Lei","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Core The Saban Research Institute, Children's Hospital Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"deBruyn","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Dolinger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology NYU Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12247569"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02586-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003100"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504837"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003649"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad083"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002632"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad216"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003727"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz085"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac197"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002298"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.02.055"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-015-3517-3"},{"key":"e_1_2_7_16_1","first-page":"319","article-title":"Transabdominal ultrasound for standardized measurement of bowel wall thickness in normal children and those with Crohn's disease","volume":"16","author":"Chiorean L","year":"2014","journal-title":"Med 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