{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:36:37Z","timestamp":1784932597480,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated the safety and efficacy of standardized minimally invasive hydrostatic low\u2010volume saline enemas in infants with a birth weight \u22641000\u2009g or gestational age \u226428 weeks and delayed meconium passage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Conducted at the Neonatology Department of Klinikum Kassel, Germany, this monocentric controlled interventional study included a historic control group and a prospective intervention group. Infants born between January 2019 and October 2022 were included. The control group received manual enemas using varied techniques, while the intervention group underwent standardized hydrostatic low\u2010volume saline enemas at predefined intervals. Key outcomes assessed included gastrointestinal complications (necrotizing enterocolitis [NEC], focal intestinal perforation [FIP], and meconium plug syndrome [MPS]), morbidity, mortality, stool and feeding parameters, and staff evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 42 infants were included in the control group and 74 in the intervention group. NEC incidence was lower in the intervention group (4.1%) compared to the control group (9.5%), as was the rate of FIP (2.7% vs. 7.1%). Morbidity showed a decreasing trend in the intervention group (6.8% vs. 16.7%), and the combined morbidity and mortality rate was significantly lower (6.8% vs. 19.1%). Despite reduced stool frequency, enteral feeding tolerance improved in the intervention group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An unstandardized approach to rectal interventions may increase the need for surgical interventions, whereas standardized hydrostatic low\u2010volume saline enemas are a safe and effective alternative to conventional rectal interventions, offering improved comfort and potentially reducing intestinal morbidity in infants with a birth weight \u22641000\u2009g or gestational age \u226428 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Identification Number<\/jats:title><jats:p>DRKS00024191 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/de\/trial\/DRKS00024191\">https:\/\/drks.de\/search\/de\/trial\/DRKS00024191<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70055","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:19:21Z","timestamp":1746757161000},"page":"104-112","source":"Crossref","is-referenced-by-count":2,"title":["Hydrostatic low\u2010volume enemas in infants with birth weight \u22641000\u2009g or gestational age \u226428 weeks: A controlled interventional study"],"prefix":"10.1002","volume":"81","author":[{"given":"Tabea","family":"Stock","sequence":"first","affiliation":[{"name":"Children's Hospital Kassel, Klinikum Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Kamp","sequence":"additional","affiliation":[{"name":"Children's Hospital Kassel, Klinikum Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Waitz","sequence":"additional","affiliation":[{"name":"Children's Hospital Kassel, Klinikum Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Riedl\u2010Seifert","sequence":"additional","affiliation":[{"name":"Children's Hospital Kassel, Klinikum Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-7185","authenticated-orcid":false,"given":"Andreas C.","family":"Jenke","sequence":"additional","affiliation":[{"name":"Children's Hospital Kassel, Klinikum Kassel Germany"},{"name":"Centre for Biomedical Education and Research (ZBAF) Witten\/Herdecke University Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198719021.001.0001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.1_Spec_No.62"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(57)80120-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.138024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00441.x"},{"key":"e_1_2_8_7_1","unstructured":"Genzel\u2010BoroviczenyO JenkeA MihatschW SchmittenbecherP. 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