{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:30:59Z","timestamp":1792063859465,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The European Liver Transplant Registry (ELTR) has been collecting data on liver transplantation (LT) in Europe since 1968. The aim of this report is to outline the number, techniques utilized, indications for, and outcomes of pediatric LT (pLT) in Europe, focusing on the Year 2022 in comparison to the preceding 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from ELTR and Eurotransplant (ET). Summary statistics were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 2022, 585 pLTs were performed in Europe. The annual number of pLT decreased for the third consecutive year. Living donor LT represented 34% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009201) of pLT. The proportion of living donation (LD) remained stable over time. The major indication for pLT in Europe is biliary atresia. Donor age is increasing overall and is associated with worse graft survival. Graft and patient survival were impacted by both types of donors and types of grafts, and were significantly worse after re\u2010transplantation. Most graft failures (77%) and deaths (82%) occurred within the first 6 months after pLT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Annual numbers of pLT in Europe are decreasing over time. Given that the proportion of LD has remained stable, the shortage of deceased donor organs may not be the major reason for this trend, and other factors play a role. A focus on improving perioperative care is needed because the risk of graft loss and mortality is highest in the first 6 months after transplantation. New techniques like ex\u2010situ machine perfusion may help mitigate risks with declining quality of deceased donor liver grafts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70065","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T03:55:02Z","timestamp":1747022102000},"page":"82-90","source":"Crossref","is-referenced-by-count":8,"title":["Update on pediatric liver transplantation in Europe 2022: An ELITA\u2010ESPGHAN report"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-2667","authenticated-orcid":false,"given":"Norman","family":"Junge","sequence":"first","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases Division for Pediatric Gastroenterology and Hepatology, Hannover Medical School Hannover Germany"},{"name":"European Reference Network TransplantChild Madrid Spain"},{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Karam","sequence":"additional","affiliation":[{"name":"The European Society for Organ Transplantation Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermien","family":"Hartog","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery &amp; Liver Transplantation University Medical Centre Groningen Groningen The Netherlands"},{"name":"European Liver and Intestine Transplant Association Board Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Adam","sequence":"additional","affiliation":[{"name":"The European Society for Organ Transplantation Amsterdam The Netherlands"},{"name":"European Liver and Intestine Transplant Association Board Padova Italy"},{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP H\u00f4pital Paul Brousse Universit\u00e9 Paris\u2010Saclay Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cailliez","sequence":"additional","affiliation":[{"name":"The European Society for Organ Transplantation Amsterdam The Netherlands"},{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation AP\u2010HP H\u00f4pital Paul Brousse Universit\u00e9 Paris\u2010Saclay Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Indolfi","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Meyer Children's Hospital IRCCS Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Samyn","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Paediatric Liver, GI and Nutrition service King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Stephenne","sequence":"additional","affiliation":[{"name":"European Reference Network TransplantChild Madrid Spain"},{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Department of Surgery, Division of Paediatric Surgery, Cliniques Universitaires Saint\u2010Luc Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor Lucian","family":"Pop","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"\u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 2ndPediatric Clinic and Center of Expertise in Pediatric Liver Rare Disorders Emergency Clinical Hospital for Children Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Waisbourd\u2010Zinman","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Schneider Children's Medical Center of Israel, Institute for Gastroenterology Nutrition and Liver Diseases Petach Tikva Israel"},{"name":"Felsenstein Medical Research Center, Faculty of Medicine and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Kohlmaier","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Department of Paediatrics and Adolescent Medicine, Division of General Paediatrics Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaia","family":"Zellos","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"First Department of Pediatrics, Aghia Sophia Children's Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mancell","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Department of Nutrition &amp; Dietetics King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gonzales","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Pediatric Hepatology &amp; Pediatric Liver Transplant Department Centre de R\u00e9f\u00e9rence de l'Atr\u00e9sie des Voies Biliaires et des Cholestases G\u00e9n\u00e9tiques, Fili\u00e8re de Sant\u00e9 des Maladies Rares du Foie de l'enfant et de l'adulte, Assistance Publique\u2010H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris\u2010Saclay, CHU Bic\u00eatre Paris France"},{"name":"INSERM, UMR\u2010S 1193, Hepatinov Universit\u00e9 Paris\u2010Saclay Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Nicastro","sequence":"additional","affiliation":[{"name":"European Reference Network TransplantChild Madrid Spain"},{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Pediatric Hepatology, Gastroenterology, and Transplantation Unit Hospital Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Quintero","sequence":"additional","affiliation":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Pediatric Hepatology and Liver Transplant Department Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Heaton","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Reding","sequence":"additional","affiliation":[{"name":"Department of Surgery, Transplantation and Abdominal Surgery Section Cliniques Universitaires Saint\u2010Luc, UCLouvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Branchereau","sequence":"additional","affiliation":[{"name":"Bic\u00eatre Hospital, GHU Paris Saclay Assistance Publique H\u00f4pitaux de Paris (AP\u2010HP) Paris\u2010Saclay University Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Gupte","sequence":"additional","affiliation":[{"name":"Birmimgham Women's and Childrens Hospital NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Schmelzle","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Fischer","sequence":"additional","affiliation":[{"name":"University Transplant Center, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kalicinski","sequence":"additional","affiliation":[{"name":"European Reference Network TransplantChild Madrid Spain"},{"name":"Department of Pediatric Surgery and Organ Transplantation Children's Memorial Health Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Colledan","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit \u201cPapa Giovanni XXIII\u201d Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Lopez","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department Hospital Infantil Universitario \u201cLa Paz\u201d Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben H.","family":"de Kleine","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery &amp; Liver Transplantation University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"European Reference Network TransplantChild Madrid Spain"},{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee Geneva Switzerland"},{"name":"Department of Gastroenterology, Hepatology and Nutrition Children's Health Ireland and University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the European Liver and Intestine Transplant Association (ELITA) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Recipient\u2010specific risk factors impairing patient and graft outcome after pediatric liver transplantation\u2014Analysis of 858 transplantations in 38 years","volume":"8","author":"Leiskau C","year":"2021","journal-title":"Children (Basel, Switzerland)"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32223"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25433"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26529"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-057424"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000080271.20145.07"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.01.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CLD.0000000000000036"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(24)00255-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006273"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002446"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082142"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002283"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.11.031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25025"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.12.012"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:11:59Z","timestamp":1754914319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jpn3.70065"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70065","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]}}}