{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:04:03Z","timestamp":1792098243845,"version":"4.4.0"},"reference-count":145,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Abdominal pain related disorders of gut\u2013brain interaction (AP\u2010DGBIs) such as irritable bowel syndrome (IBS) and functional abdominal pain\u2010not otherwise specified (FAP) are common conditions in children, significantly impacting quality of life. This treatment guideline for IBS and FAP in children of 4\u201318 years is a collaborative effort of the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN and NASPGHAN). We aim to comprehensively review the current evidence on treatment options and offer evidence\u2010based recommendations with utility across all treatment settings worldwide, as well as to provide methodological directions for future research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The guideline development followed the \u201cGrading of Recommendations Assessment, Development and Evaluation\u201d (GRADE) approach, which is in accordance with the GRADE handbook and supported by the World Health Organization. The Guideline Development Group (GDG) comprised clinical experts, representing ESPGHAN, NASPGHAN, and Cochrane. Individual members have put forward a final consensus list of treatment options, which were then translated into \u201cpatient, intervention, comparison, outcome\u201d (PICO) format options. Prospective agreement on decision thresholds for efficacy and safety outcomes was reached through a Delphi process among the GDG to support GRADEing of the literature. Consensus voting was used to finalize recommendations, and a treatment algorithm was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Systematic literature searches for this output identified 86 original randomized controlled trials assessing treatment of IBS and FAP. Consensus was reached for 25 GRADEd recommendations. Ten best practice statements were formulated, and guidance for future research methodology was proposed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This guideline represents the first collaborative output of ESPGHAN and NASPGHAN on treatment options for AP\u2010DGBIs. Systematic review of the evidence has exposed major evidence gaps for the treatment of these disorders and incentivizes large pediatric trials, particularly on treatment options for which, to date, no evidence exists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70070","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:10:42Z","timestamp":1748585442000},"page":"442-471","source":"Crossref","is-referenced-by-count":49,"title":["ESPGHAN\/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain\u2010not otherwise specified in children aged 4\u201318 years"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7465-7549","authenticated-orcid":false,"given":"Jip","family":"Groen","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Pediatric Gastroenterology Amsterdam The Netherlands"},{"name":"Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism University of Amsterdam Amsterdam The Netherlands"},{"name":"University of Amsterdam, Amsterdam UMC, Amsterdam Reproduction and Development research institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Gordon","sequence":"additional","affiliation":[{"name":"School of Medicine University of Central Lancashire Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Chogle","sequence":"additional","affiliation":[{"name":"Children's Hospital of Orange County Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Benninga","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Pediatric Gastroenterology Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Borlack","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Montefiore, Albert Einstein College of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Darbari","sequence":"additional","affiliation":[{"name":"Children's National Hospital, George Washington University School of Medicine and Health Sciences Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"Dolinsek","sequence":"additional","affiliation":[{"name":"University Medical Centre Maribor Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Khlevner","sequence":"additional","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannibal","family":"Person","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinarani","family":"Sanghavi","sequence":"additional","affiliation":[{"name":"Children's Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Snyder","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Thapar","sequence":"additional","affiliation":[{"name":"Queensland Children's Hospital, School of Medicine University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arine","family":"Vlieger","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Sinopoulou","sequence":"additional","affiliation":[{"name":"University of Central Lancashire Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merit","family":"Tabbers","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Pediatric Gastroenterology Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Saps","sequence":"additional","affiliation":[{"name":"University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126982","article-title":"Epidemiology of pediatric functional abdominal pain disorders: a meta\u2010analysis","volume":"10","author":"Korterink JJ","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cgh.2007.12.019","article-title":"Chronic abdominal pain and depressive symptoms: analysis of the national longitudinal study of adolescent health","volume":"6","author":"Youssef NN","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jpeds.2015.07.058","article-title":"Annual costs of care for pediatric irritable bowel syndrome, functional abdominal pain, and functional abdominal pain syndrome","volume":"167","author":"Hoekman DR","year":"2015","journal-title":"J Pediatr"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jpeds.2016.04.008","article-title":"Prevalence of functional gastrointestinal disorders in children and adolescents","volume":"177","author":"Lewis ML","year":"2016","journal-title":"J Pediatr"},{"issue":"5","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/MPG.0000000000000850","article-title":"School attendance in children with functional abdominal pain and inflammatory bowel diseases","volume":"61","author":"Assa A","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/MPG.0b013e3181de0639","article-title":"A million\u2010dollar work\u2010up for abdominal pain: is it worth it?","volume":"51","author":"Dhroove G","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2016.02.015","article-title":"Functional disorders: children and adolescents","volume":"150","author":"Hyams JS","year":"2016","journal-title":"Gastroenterology"},{"issue":"4","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MPG.0000000000000452","article-title":"IBS and FAPS in children: a comparison of psychological and clinical characteristics","volume":"59","author":"Rutten JMTM","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/17474124.2022.2055547","article-title":"Dietary interventions for functional abdominal pain disorders in children: a systematic review and meta\u2010analysis","volume":"16","author":"Bruijn CM","year":"2022","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"6","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1001\/jamapediatrics.2022.0313","article-title":"Psychosocial interventions for the treatment of functional abdominal pain disorders in children: a systematic review and meta\u2010analysis","volume":"176","author":"Gordon M","year":"2022","journal-title":"JAMA Pediatr"},{"issue":"6","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-042101","article-title":"Pharmacologic treatment in functional abdominal pain disorders in children: a systematic review","volume":"147","author":"Rexwinkel R","year":"2021","journal-title":"Pediatrics"},{"issue":"2","key":"e_1_2_10_13_1","article-title":"Probiotics for management of functional abdominal pain disorders in children","volume":"2","author":"Wallace C","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41572-020-00222-5","article-title":"Paediatric functional abdominal pain disorders","volume":"6","author":"Thapar N","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MPG.0000000000000266","article-title":"Evaluation and treatment of functional constipation in infants and children: evidence\u2010based recommendations from ESPGHAN and NASPGHAN","volume":"58","author":"Tabbers MM","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_10_16_1","volume-title":"GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Sch\u00fcnemann HBJ","year":"2013"},{"issue":"1","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2023-002166","article-title":"ESPGHAN and NASPGHAN 2023 protocol for paediatric FAPD treatment guidelines (standard operating procedure)","volume":"7","author":"Gordon M","year":"2023","journal-title":"BMJ Paediatr Open"},{"issue":"1","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2022-001067","article-title":"BSG 2024 IBD guidelines protocol (standard operating procedures)","volume":"10","author":"Gordon M","year":"2023","journal-title":"BMJ Open Gastroenterol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jpeds.2020.02.032","article-title":"A core outcome set for clinical trials in pediatric functional abdominal pain disorders","volume":"221","author":"Zeevenhooven J","year":"2020","journal-title":"J Pediatr"},{"issue":"4","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5662\/wjm.v11.i4.116","article-title":"Delphi methodology in healthcare research: how to decide its appropriateness","volume":"11","author":"Nasa P","year":"2021","journal-title":"World J Methodol"},{"issue":"3","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053246","article-title":"Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development and evaluation (GRADE) evidence to decision (EtD) frameworks: a protocol for a randomised methodological study (GRADE\u2010THRESHOLD)","volume":"12","author":"Morgano GP","year":"2022","journal-title":"BMJ Open"},{"issue":"1","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"i73","DOI":"10.1093\/ecco-jcc\/jjad212.0042","article-title":"DOP02 developing explicit thresholds for outcomes to inform (GRADE) evidence to decision frameworks for inflammatory bowel disease guidelines","volume":"18","author":"Shaban N","year":"2024","journal-title":"J Crohn's Colitis"},{"issue":"1","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2023-001334","article-title":"Prepublication abstract\u2010only reports compared with full\u2010text manuscripts for randomised controlled trials in inflammatory bowel disease: a systematic review","volume":"11","author":"Sinopoulou V","year":"2024","journal-title":"BMJ Open Gastroenterol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2023-001337","article-title":"Quality of reporting of inflammatory bowel disease trials: a systematic review","author":"Gordon MKJ","year":"2024","journal-title":"BMJ Open Gastro"},{"issue":"4","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. Rating the quality of evidence\u2014study limitations (risk of bias)","volume":"64","author":"Guyatt GH","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"i2016","DOI":"10.1136\/bmj.i2016","article-title":"GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 1: introduction","volume":"353","author":"Alonso\u2010Coello P","year":"2016","journal-title":"BMJ"},{"issue":"5","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1053\/j.gastro.2007.08.072","article-title":"Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomized controlled trial","volume":"133","author":"Vlieger AM","year":"2007","journal-title":"Gastroenterology"},{"issue":"8","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00431-013-1990-y","article-title":"Brief hypnotherapeutic\u2010behavioral intervention for functional abdominal pain and irritable bowel syndrome in childhood: a randomized controlled trial","volume":"172","author":"Gulewitsch MD","year":"2013","journal-title":"Eur J Pediatr"},{"issue":"12","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/MEG.0000000000000984","article-title":"Comparison of gut\u2010directed hypnotherapy and unspecific hypnotherapy as self\u2010help format in children and adolescents with functional abdominal pain or irritable bowel syndrome: a randomized pilot study","volume":"29","author":"Gulewitsch MD","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"5","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jamapediatrics.2017.0091","article-title":"Home\u2010based hypnotherapy self\u2010exercises vs individual hypnotherapy with a therapist for treatment of pediatric irritable bowel syndrome, functional abdominal pain, or functional abdominal pain syndrome: a randomized clinical trial","volume":"171","author":"Rutten JMTM","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"6","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.3390\/jcm9061797","article-title":"Pain neuroscience education for children with functional abdominal pain disorders: a randomized comparative pilot study","volume":"9","author":"Pas R","year":"2020","journal-title":"J Clin Med"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2431-6-29","article-title":"Evaluation of guided imagery as treatment for recurrent abdominal pain in children: a randomized controlled trial","volume":"6","author":"Weydert JA","year":"2006","journal-title":"BMC Pediatr"},{"issue":"5","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(09)60705-8","article-title":"1007 feasibility and efficacy of pilot study investigating a school nurse administered guided imagery program for childhood functional abdominal pain","volume":"136","author":"Youssef NN","year":"2009","journal-title":"Gastroenterology"},{"issue":"5","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"e890","DOI":"10.1542\/peds.2009-0028","article-title":"Audio\u2010recorded guided imagery treatment reduces functional abdominal pain in children: a pilot study","volume":"124","author":"Tilburg MAL","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1651-2227.2006.00028.x","article-title":"A new method for the treatment of recurrent abdominal pain of prolonged negative stress origin","volume":"96","author":"Alfv\u00e9n G","year":"2007","journal-title":"Acta Paediatr (Stockholm)"},{"issue":"1","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.beth.2018.05.002","article-title":"Internet\u2010delivered exposure\u2010based cognitive\u2010behavioral therapy for adolescents with functional abdominal pain or functional dyspepsia: a feasibility study","volume":"50","author":"Bonnert M","year":"2019","journal-title":"Behav Ther"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpeds.2020.10.060","article-title":"Cognitive behavior therapy tailored to anxiety symptoms improves pediatric functional abdominal pain outcomes: a randomized clinical trial","volume":"230","author":"Cunningham NR","year":"2021","journal-title":"J Pediatr"},{"issue":"1","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.mpg.0000226373.10871.76","article-title":"Treatment of nonorganic recurrent abdominal pain: cognitive\u2010behavioral family intervention","volume":"43","author":"Duarte MA","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s12529-012-9228-3","article-title":"Evaluation of a cognitive\u2010behavioral pain management program for children with chronic abdominal pain: a randomized controlled study","volume":"20","author":"Gro\u00df M","year":"2013","journal-title":"Int J Behav Med"},{"issue":"1","key":"e_1_2_10_40_1","first-page":"47","article-title":"Treatment of recurrent abdominal pain: components analysis of four treatment protocols","volume":"31","author":"Humphreys PA","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"11","key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.cgh.2018.11.043","article-title":"Clinical and cost effectiveness of online cognitive behavioral therapy in children with functional abdominal pain disorders","volume":"17","author":"Lalouni M","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ajg.2010.106","article-title":"Cognitive\u2010behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms","volume":"105","author":"Levy RL","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.2147\/JPR.S221227","article-title":"Effects and experiences of families following a web\u2010based psychosocial intervention for children with functional abdominal pain and their parents: a mixed\u2010methods pilot randomized controlled trial","volume":"12","author":"Nieto R","year":"2019","journal-title":"J Pain Res"},{"issue":"5","key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jpepsy\/jsi063","article-title":"A randomized controlled trial of a cognitive\u2010behavioral family intervention for pediatric recurrent abdominal pain","volume":"30","author":"Robins PM","year":"2005","journal-title":"J Pediatr Psychol"},{"issue":"2","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1037\/0022-006X.57.2.294","article-title":"Cognitive\u2010behavioral treatment of recurrent nonspecific abdominal pain in children: an analysis of generalization, maintenance, and side effects","volume":"57","author":"Sanders MR","year":"1989","journal-title":"J Consult Clin Psychol"},{"issue":"2","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1037\/0022-006X.62.2.306","article-title":"The treatment of recurrent abdominal pain in children: a controlled comparison of cognitive\u2010behavioral family intervention and standard pediatric care","volume":"62","author":"Sanders MR","year":"1994","journal-title":"J Consult Clin Psychol"},{"issue":"5","key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"e1163","DOI":"10.1542\/peds.2013-0242","article-title":"Cognitive behavior therapy for pediatric functional abdominal pain: a randomized controlled trial","volume":"132","author":"Veek SMC","year":"2013","journal-title":"Pediatrics"},{"issue":"12","key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1097\/j.pain.0000000000002288","article-title":"Internet\u2010delivered cognitive behavioral therapy for youth with functional abdominal pain: a randomized clinical trial testing differential efficacy by patient subgroup","volume":"162","author":"Walker LS","year":"2021","journal-title":"Pain"},{"issue":"4","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/08870440903477212","article-title":"A randomised controlled trial of written self\u2010disclosure for functional recurrent abdominal pain in youth","volume":"26","author":"Wallander JL","year":"2011","journal-title":"Psychol Health"},{"issue":"6","key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.14309\/ajg.0000000000001191","article-title":"Do children with functional abdominal pain benefit more from a pain\u2010specific cognitive\u2010behavioral intervention than from an unspecific attention control intervention? Results of a randomized controlled trial","volume":"116","author":"Warschburger P","year":"2021","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"e_1_2_10_51_1","first-page":"201","article-title":"A pilot study of \u201cGutstrong\u201d for adolescents with functional gastrointestinal disorders","volume":"1","author":"Wassom MC","year":"2013","journal-title":"Clin Pract Pediatr Psychol"},{"issue":"7","key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/jpepsy\/jsj065","article-title":"Online psychological treatment for pediatric recurrent pain: a randomized evaluation","volume":"31","author":"Hicks CL","year":"2006","journal-title":"J Pediatr Psychol"},{"issue":"4","key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/j.pain.0000000000000800","article-title":"Brief telephone\u2010delivered cognitive behavioral therapy targeted to parents of children with functional abdominal pain: a randomized controlled trial","volume":"158","author":"Levy RL","year":"2017","journal-title":"Pain"},{"issue":"1","key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1586\/17434440.4.1.23","article-title":"P\u2010Stim\u2122 auricular electroacupuncture stimulation device for pain relief","volume":"4","author":"Sator\u2010Katzenschlager SM","year":"2007","journal-title":"Expert Rev Med Devices"},{"issue":"4","key":"e_1_2_10_55_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/00002508-199812000-00009","article-title":"Percutaneous electrical nerve stimulation (PENS): a complementary therapy for the management of pain secondary to bony metastasis","volume":"14","author":"Ahmed HE","year":"1998","journal-title":"Clin J Pain"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.actamat.2015.06.031","article-title":"Effect of environmental sulfur on the structure of alumina scales formed on Ni\u2010base alloys","volume":"97","author":"Liu X","year":"2015","journal-title":"Acta Mater"},{"issue":"1","key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/08990229409028858","article-title":"Innervation of the rat external auditory meatus: a retrograde tracing study","volume":"11","author":"Folan\u2010curran J","year":"1994","journal-title":"Somatosens Mot Res"},{"issue":"3","key":"e_1_2_10_58_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0165-1838(82)90003-0","article-title":"The central projections of the trigeminal, facial, glossopharyngeal and vagus nerves: an autoradiographic study in the rat","volume":"6","author":"Contreras RJ","year":"1982","journal-title":"J Auton Nerv Syst"},{"issue":"10","key":"e_1_2_10_59_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S2468-1253(17)30253-4","article-title":"Neurostimulation for abdominal pain\u2010related functional gastrointestinal disorders in adolescents: a randomised, double\u2010blind, sham\u2010controlled trial","volume":"2","author":"Kovacic K","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"9","key":"e_1_2_10_60_1","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.cgh.2019.10.012","article-title":"Efficacy of auricular neurostimulation in adolescents with irritable bowel syndrome in a randomized, double\u2010blind trial","volume":"18","author":"Krasaelap A","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/MPG.0000000000003428","article-title":"Neonatal antibiotics and food allergy are associated with FGIDs at 4\u20106 years of age","volume":"74","author":"Kamphorst K","year":"2022","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"e_1_2_10_62_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/nmo.12340","article-title":"Use of antibiotics in infancy and childhood and risk of recurrent abdominal pain\u2014a Swedish birth cohort study","volume":"26","author":"Uusij\u00e4rvi A","year":"2014","journal-title":"Neurogastroenterol Motil"},{"issue":"5","key":"e_1_2_10_63_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5152\/tjg.2016.16301","article-title":"Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: a randomized controlled trial","volume":"27","author":"Ba\u015ft\u00fcrk A","year":"2016","journal-title":"Turk J Gastroenterol"},{"issue":"6","key":"e_1_2_10_64_1","article-title":"A randomized double\u2010blind placebo\u2010controlled trial of Lactobacillus reuteri for chronic functional abdominal pain in children","volume":"25","author":"Eftekhari K","year":"2015","journal-title":"Iran J Ped"},{"issue":"6","key":"e_1_2_10_65_1","doi-asserted-by":"crossref","first-page":"e1445","DOI":"10.1542\/peds.2010-0467","article-title":"A randomized controlled trial of Lactobacillus GG in children with functional abdominal pain","volume":"126","author":"Francavilla R","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"e_1_2_10_66_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2036.2006.03175.x","article-title":"A randomized double\u2010blind placebo\u2010controlled trial of Lactobacillus GG for abdominal pain disorders in children","volume":"25","author":"Gawro\u0144ska A","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"e_1_2_10_67_1","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1097\/MCG.0000000000000528","article-title":"A mixture of 3 bifidobacteria decreases abdominal pain and improves the quality of life in children with irritable bowel syndrome: a multicenter, randomized, double\u2010blind, placebo\u2010controlled, crossover trial","volume":"51","author":"Giannetti E","year":"2017","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"e_1_2_10_68_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MPG.0b013e3181ca4d95","article-title":"VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo\u2010controlled, double\u2010blind, crossover study","volume":"51","author":"Guandalini S","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"e_1_2_10_69_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1097\/MPG.0000000000001478","article-title":"Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain in children: RCT study","volume":"64","author":"Jadre\u0161in O","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"12","key":"e_1_2_10_70_1","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1016\/j.clnu.2020.04.019","article-title":"Lactobacillus reuteri DSM 17938 is effective in the treatment of functional abdominal pain in children: results of the double\u2010blind randomized study","volume":"39","author":"Jadre\u0161in O","year":"2020","journal-title":"Clin Nutr"},{"issue":"12","key":"e_1_2_10_71_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3345\/cep.2022.00339","article-title":"Ability of polymicrobial probiotic and mono\u2010strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial","volume":"65","author":"Jafari SS","year":"2022","journal-title":"Clin Exp Pediatr"},{"issue":"11","key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/apa.13992","article-title":"Lactobacillus reuteri DSM 17938 and a placebo both significantly reduced symptoms in children with functional abdominal pain","volume":"106","author":"Maragkoudaki M","year":"2017","journal-title":"Acta Paediatr (Stockholm)"},{"issue":"12","key":"e_1_2_10_73_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3345\/cep.2019.01613","article-title":"Evaluating the effects of probiotics in pediatrics with recurrent abdominal pain","volume":"63","author":"Rahmani P","year":"2020","journal-title":"Clin Exp Pediatr"},{"issue":"10","key":"e_1_2_10_74_1","doi-asserted-by":"crossref","first-page":"E68","DOI":"10.1111\/j.1440-1754.2010.01797.x","article-title":"Lactobacillus reuteri in children with functional abdominal pain (FAP)","volume":"50","author":"Romano C","year":"2014","journal-title":"J Paediatr Child Health"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1744-1161(11)70513-0","article-title":"PP223\u2010MON the use of Lactobacillus GG in children with functional abdominal pain: a double\u2010blind randomized control trial","volume":"6","author":"Sabbi T","year":"2011","journal-title":"Clin Nutr Suppl"},{"issue":"1","key":"e_1_2_10_76_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40272-022-00536-9","article-title":"Efficacy and safety of the adjuvant use of probiotic Bacillus clausii strains in pediatric irritable bowel syndrome: a randomized, double\u2010blind, placebo\u2010controlled study","volume":"25","author":"V\u00e1zquez\u2010Frias R","year":"2023","journal-title":"Pediatric Drugs"},{"key":"e_1_2_10_77_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jpeds.2016.04.003","article-title":"Lactobacillus reuteri DSM 17938 for the management of functional abdominal pain in childhood: a randomized, double\u2010blind, placebo\u2010controlled trial","volume":"174","author":"Weizman Z","year":"2016","journal-title":"J Pediatr"},{"issue":"4","key":"e_1_2_10_78_1","doi-asserted-by":"crossref","DOI":"10.5812\/ircmj.17(4)2015.23844","article-title":"Comparison of the effects of pH\u2010dependent peppermint oil and synbiotic lactol (Bacillus coagulans + fructooligosaccharides) on childhood functional abdominal pain: a randomized placebo\u2010controlled study","volume":"17","author":"Asgarshirazi M","year":"2015","journal-title":"Iran Red Crescent Med J"},{"issue":"2","key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpeds.2005.05.015","article-title":"The use of Lactobacillus GG in irritable bowel syndrome in children: a double\u2010blind randomized control trial","volume":"147","author":"Bausserman M","year":"2005","journal-title":"J Pediatr"},{"issue":"2","key":"e_1_2_10_80_1","first-page":"194","article-title":"Effect of a synbiotic on functional abdominal pain in childhood","volume":"12","author":"Gholizadeh A","year":"2021","journal-title":"Caspian J Intern Med"},{"issue":"5","key":"e_1_2_10_81_1","first-page":"1255","article-title":"Probiotic for irritable bowel syndrome in pediatric patients: a randomized controlled clinical trial","volume":"7","author":"Kianifar H","year":"2015","journal-title":"Electron Physician"},{"key":"e_1_2_10_82_1","first-page":"426","article-title":"Efficiency and immunologic effects of synbiotics in children with functional abdominal pain","volume":"62","author":"Otuzbir A","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"e_1_2_10_83_1","first-page":"56","article-title":"Synbiotic containing Bacillus coagulans and fructo\u2010oligosaccharides for functional abdominal pain in children","volume":"8","author":"Saneian H","year":"2015","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"4","key":"e_1_2_10_84_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3920\/BM2017.0129","article-title":"Efficacy of Bacillus coagulans unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study","volume":"9","author":"Sudha MR","year":"2018","journal-title":"Benef Microbes"},{"issue":"5","key":"e_1_2_10_85_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3920\/BM2014.0157","article-title":"Safety of probiotics and synbiotics in children under 18 years of age","volume":"6","author":"Nieuwboer M","year":"2015","journal-title":"Benef Microbes"},{"issue":"1","key":"e_1_2_10_86_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1067\/mpd.2001.109606","article-title":"Enteric\u2010coated, pH\u2010dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children","volume":"138","author":"Kline RM","year":"2001","journal-title":"J Pediatr"},{"issue":"6","key":"e_1_2_10_87_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/apt.17179","article-title":"Systematic review and meta\u2010analysis: efficacy of peppermint oil in irritable bowel syndrome","volume":"56","author":"Ingrosso MR","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"e_1_2_10_88_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000207","article-title":"What do monoamines do in pain modulation?","volume":"10","author":"Bannister K","year":"2016","journal-title":"Curr Opin Support Palliat Care"},{"issue":"7","key":"e_1_2_10_89_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell MC","year":"2013","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"e_1_2_10_90_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrgastro.2015.121","article-title":"Towards a systems view of IBS","volume":"12","author":"Mayer EA","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"e_1_2_10_91_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1053\/j.gastro.2016.02.027","article-title":"Biopsychosocial aspects of functional gastrointestinal disorders","volume":"150","author":"Van Oudenhove L","year":"2016","journal-title":"Gastroenterology"},{"issue":"5","key":"e_1_2_10_92_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jpeds.2007.10.012","article-title":"Double\u2010blind placebo\u2010controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents","volume":"152","author":"Bahar RJ","year":"2008","journal-title":"J Pediatr"},{"issue":"4","key":"e_1_2_10_93_1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1053\/j.gastro.2009.06.060","article-title":"Multicenter, randomized, placebo\u2010controlled trial of amitriptyline in children with functional gastrointestinal disorders","volume":"137","author":"Saps M","year":"2009","journal-title":"Gastroenterology"},{"issue":"4","key":"e_1_2_10_94_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/jgh.15765","article-title":"Efficacy of amitriptyline in pediatric functional abdominal pain disorders: a randomized placebo\u2010controlled trial","volume":"37","author":"Seetharaman J","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"e_1_2_10_95_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41395-018-0222-5","article-title":"Effect of antidepressants and psychological therapies in irritable bowel syndrome: an updated systematic review and meta\u2010analysis","volume":"114","author":"Ford AC","year":"2019","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"e_1_2_10_96_1","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1097\/MPG.0000000000003822","article-title":"Drugs in focus: domperidone","volume":"77","author":"Puoti MG","year":"2023","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"e_1_2_10_97_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3748\/wjg.v25.i1.95","article-title":"Autonomic functions and gastric motility in children with functional abdominal pain disorders","volume":"25","author":"Karunanayake A","year":"2019","journal-title":"World J Gastroenterol"},{"issue":"5","key":"e_1_2_10_98_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/MPG.0000000000001819","article-title":"Randomized controlled clinical trial on value of domperidone in functional abdominal pain in children","volume":"66","author":"Karunanayake A","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"e_1_2_10_99_1","doi-asserted-by":"crossref","DOI":"10.5812\/semj-128504","article-title":"Effect of domperidone on children with functional abdominal pain: a randomized controlled clinical trial","volume":"24","author":"Tavakoli Haghighiand N","year":"2023","journal-title":"Shiraz E\u2010Med J"},{"issue":"9","key":"e_1_2_10_100_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1185\/03007998009109491","article-title":"Use of the peripheral dopamine antagonist, domperidone, in the management of gastro\u2010intestinal symptoms in patients with irritable bowel syndrome","volume":"6","author":"Milo R","year":"1980","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"e_1_2_10_101_1","first-page":"1","article-title":"Risk of adverse events associated with domperidone and metoclopramide in gastroparesis: systematic review and meta\u2010analysis","volume":"23","author":"Junqueira DR","year":"2023","journal-title":"Drugs R&D"},{"issue":"1","key":"e_1_2_10_102_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jpeds.2012.12.096","article-title":"Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children","volume":"163","author":"Rodriguez L","year":"2013","journal-title":"J Pediatr"},{"issue":"6","key":"e_1_2_10_103_1","first-page":"1367","article-title":"Cyproheptadine for the treatment of functional abdominal pain in childhood: a double\u2010blinded randomized placebo\u2010controlled trial","volume":"60","author":"Sadeghian M","year":"2008","journal-title":"Minerva Pediatr"},{"issue":"11","key":"e_1_2_10_104_1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/archdischild-2021-323571","article-title":"Benefits of dietary fibre for children in health and disease","volume":"107","author":"Hojsak I","year":"2022","journal-title":"Arch Dis Child"},{"issue":"2","key":"e_1_2_10_105_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41575-020-00375-4","article-title":"Dietary fibre in gastrointestinal health and disease","volume":"18","author":"Gill SK","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"e_1_2_10_106_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: metabolism of nutrients and other food components","volume":"57","author":"Rowland I","year":"2018","journal-title":"Eur J Nutr"},{"issue":"12","key":"e_1_2_10_107_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1001\/archpedi.1985.02140140050025","article-title":"The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent, abdominal pain. Results in a prospective, double\u2010blind, randomized, controlled trial","volume":"139","author":"Feldman W","year":"1985","journal-title":"Am J Dis Child"},{"issue":"20","key":"e_1_2_10_108_1","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.3748\/wjg.v19.i20.3062","article-title":"Glucomannan for abdominal pain\u2010related functional gastrointestinal disorders in children: a randomized trial","volume":"19","author":"Horvath A","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"1","key":"e_1_2_10_109_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MPG.0000000000003622","article-title":"Efficacy of oral psyllium in pediatric irritable bowel syndrome: a double\u2010blind randomized control trial","volume":"76","author":"Menon J","year":"2023","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"e_1_2_10_110_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3748\/wjg.v19.i2.235","article-title":"Partially hydrolyzed guar gum in pediatric functional abdominal pain","volume":"19","author":"Romano C","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"5","key":"e_1_2_10_111_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2016.03.045","article-title":"Psyllium fiber reduces abdominal pain in children with irritable bowel syndrome in a randomized, double\u2010blind trial","volume":"15","author":"Shulman RJ","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"e_1_2_10_112_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2982.2008.01260.x","article-title":"A placebo\u2010controlled trial of the 5\u2010HT1A agonist R\u2010137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia","volume":"21","author":"Tack J","year":"2009","journal-title":"Neurogastroenterol Motil"},{"issue":"11","key":"e_1_2_10_113_1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/apt.17479","article-title":"Buspirone for early satiety and symptoms of gastroparesis: a multi\u2010centre, randomised, placebo\u2010controlled, double\u2010masked trial (BESST)","volume":"57","author":"Parkman HP","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"e_1_2_10_114_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.14309\/ajg.0000000000000589","article-title":"Comparison of the efficacy of buspirone and placebo in childhood functional abdominal pain: a randomized clinical trial","volume":"115","author":"Badihian N","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"e_1_2_10_115_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-2999(87)90475-4","article-title":"Modification of \u03b11\u2010receptor\u2010operated channels by mebeverine in smooth muscle cells of guinea\u2010pig taenia caeci","volume":"138","author":"Den Hertog A","year":"1987","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"e_1_2_10_116_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jps.2600710123","article-title":"Heterogeneity of biochemical actions among vasodilators","volume":"71","author":"Greenslade FC","year":"1982","journal-title":"J Pharm Sci"},{"issue":"3","key":"e_1_2_10_117_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1124\/jpet.116.237271","article-title":"Potential L\u2010type voltage\u2010operated calcium channel blocking effect of drotaverine on functional models","volume":"359","author":"Patai Z","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_10_118_1","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/191026","article-title":"Mebeverine for pediatric functional abdominal pain: a randomized, placebo\u2010controlled trial","volume":"2014","author":"Pourmoghaddas Z","year":"2014","journal-title":"BioMed Res Int"},{"issue":"10","key":"e_1_2_10_119_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s13312-015-0730-y","article-title":"Efficacy and safety of drotaverine hydrochloride in children with recurrent abdominal pain: a randomized placebo controlled trial","volume":"52","author":"Narang M","year":"2015","journal-title":"Indian Pediatr"},{"issue":"5","key":"e_1_2_10_120_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3748\/wjg.v16.i5.547","article-title":"A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome","volume":"16","author":"Darvish\u2010Damavandi M","year":"2010","journal-title":"World J Gastroenterol"},{"issue":"1","key":"e_1_2_10_121_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/jcag\/gwad020","article-title":"Emerging roles of gut serotonin in regulation of immune response, microbiota composition and intestinal inflammation","volume":"7","author":"Grondin JA","year":"2023","journal-title":"J Can Assoc Gastroenterol"},{"issue":"11","key":"e_1_2_10_122_1","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/nmo.12444","article-title":"Citalopram for pediatric functional abdominal pain: a randomized, placebo\u2010controlled trial","volume":"26","author":"Roohafza H","year":"2014","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"e_1_2_10_123_1","article-title":"Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome","volume":"2011","author":"Ruepert L","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"e_1_2_10_124_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/MPG.0000000000000366","article-title":"Iyengar yoga for adolescents and young adults with irritable bowel syndrome","volume":"59","author":"Evans S","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"e_1_2_10_125_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/ejp.1862","article-title":"Dance and yoga reduced functional abdominal pain in young girls: a randomized controlled trial","volume":"26","author":"H\u00f6gstr\u00f6m S","year":"2022","journal-title":"Eur J Pain"},{"issue":"5","key":"e_1_2_10_126_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/MPG.0000000000001230","article-title":"Yoga therapy for abdominal pain\u2010related functional gastrointestinal disorders in children: a randomized controlled trial","volume":"63","author":"Korterink JJ","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"e_1_2_10_127_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1155\/2006\/731628","article-title":"A randomized trial of yoga for adolescents with irritable bowel syndrome","volume":"11","author":"Kuttner L","year":"2006","journal-title":"Pain Res Manag"},{"key":"e_1_2_10_128_1","doi-asserted-by":"crossref","DOI":"10.1177\/2058739219853689","article-title":"Effect of acupuncture combined with Astragalus injection on peripheral blood inflammatory factors in children with diarrhea\u2010predominant irritable bowel syndrome","volume":"17","author":"Xue H","year":"2019","journal-title":"Eur J Inflamm"},{"key":"e_1_2_10_129_1","unstructured":"IngoC.Auswirkungen Osteopathischer Behandlung bei Kindern mit funktionellen Bauchschmerzen: Eine klinische Studie mit 32 Kindern und Jugendlichen im Alter von 6 bis 18 Jahren in Osteopathie Schule. Dissertation.Dresden International University;2019."},{"issue":"5","key":"e_1_2_10_130_1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000510795","article-title":"Low FODMAP diet is not effective in children with functional abdominal pain: a randomized controlled trial","volume":"76","author":"Boradyn KM","year":"2020","journal-title":"Ann Nutr Metab"},{"issue":"4","key":"e_1_2_10_131_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/apt.13286","article-title":"Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome","volume":"42","author":"Chumpitazi BP","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"e_1_2_10_132_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cgh.2017.09.043","article-title":"Fructans exacerbate symptoms in a subset of children with irritable bowel syndrome","volume":"16","author":"Chumpitazi BP","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"e_1_2_10_133_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1055\/s-0034-1383653","article-title":"Positive or negative fructose breath test results do not predict response to fructose restricted diet in children with recurrent abdominal pain: results from a prospective randomized trial","volume":"226","author":"Wirth S","year":"2014","journal-title":"Klin Padiatr"},{"key":"e_1_2_10_134_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2147\/PHMT.S159925","article-title":"Serum\u2010derived bovine immunoglobulin for children with diarrhea\u2010predominant irritable bowel syndrome","volume":"9","author":"Arrouk R","year":"2018","journal-title":"Pediatr Health Med Ther"},{"issue":"4","key":"e_1_2_10_135_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/MPG.0b013e3181effa3b","article-title":"Double\u2010blind, placebo\u2010controlled antibiotic treatment study of small intestinal bacterial overgrowth in children with chronic abdominal pain","volume":"52","author":"Collins BS","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"e_1_2_10_136_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/MPG.0b013e31823a29a7","article-title":"No advantage for antibiotic treatment over placebo in Blastocystis hominis\u2010positive children with recurrent abdominal pain","volume":"54","author":"Heyland K","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"e_1_2_10_137_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.5056\/jnm.2013.19.1.90","article-title":"The incidence of irritable bowel syndrome in children using the Rome III criteria and the effect of trimebutine treatment","volume":"19","author":"Karabulut GS","year":"2013","journal-title":"J Neurogastroenterol Motil"},{"issue":"3","key":"e_1_2_10_138_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/jpc.16323","article-title":"Randomised controlled trial of melatonin for paediatric functional abdominal pain disorders","volume":"59","author":"Dipasquale V","year":"2023","journal-title":"J Paediatr Child Health"},{"issue":"2","key":"e_1_2_10_139_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/sjg.SJG_438_17","article-title":"Vitamin D supplementation in adolescents with irritable bowel syndrome: is it useful? A randomized controlled trial","volume":"24","author":"El Amrousy D","year":"2018","journal-title":"Saudi J Gastroenterol"},{"issue":"3","key":"e_1_2_10_140_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/ajg.2017.483","article-title":"Randomized double\u2010blind placebo\u2010controlled crossover trial for the diagnosis of non\u2010celiac gluten sensitivity in children","volume":"113","author":"Francavilla R","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"130","key":"e_1_2_10_141_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/00365528709091003","article-title":"Loperamide in treatment of irritable bowel syndrome\u2014a double\u2010blind placebo controlled study","volume":"22","author":"L\u00e4vo B","year":"1987","journal-title":"Scand J Gastroenterol"},{"issue":"130","key":"e_1_2_10_142_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/00365528709091004","article-title":"Loperamide treatment of the irritable bowel syndrome","volume":"22","author":"Hovdenak N","year":"1987","journal-title":"Scand J Gastroenterol"},{"issue":"10","key":"e_1_2_10_143_1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.14309\/ajg.0000000000000696","article-title":"The role of bile acids in chronic diarrhea","volume":"115","author":"Camilleri M","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"13","key":"e_1_2_10_144_1","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1016\/j.cgh.2020.02.027","article-title":"Effects of colesevelam on bowel symptoms, biomarkers, and colonic mucosal gene expression in patients with bile acid diarrhea in a randomized trial","volume":"18","author":"Vijayvargiya P","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_10_145_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jpeds.2016.12.022","article-title":"The placebo response in pediatric abdominal pain\u2010related functional gastrointestinal disorders: a systematic review and meta\u2010analysis","volume":"182","author":"Hoekman DR","year":"2017","journal-title":"J Pediatr"},{"key":"e_1_2_10_146_1","unstructured":"McMaster Forum \u2013 Living Guidelines. Accessed March 26 2024."}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:15:23Z","timestamp":1754032523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":145,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jpn3.70070"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70070","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]}}}