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Accurate prediction of the clinical course of CP in pediatric patients is crucial for effective management and improved patient outcomes. This manuscript reviews the current progress in predicting the clinical course of CP in pediatric patients, focusing on relevant studies published in medical journals. It involves the review of many recent articles and historical articles through the PubMed database. Additionally, it highlights the predictive factors, imaging modalities, and treatment plans that hold promise for better prognosis and personalized treatment approaches. CP in the pediatric population is an ever\u2010evolving field with substantially less literature than in adults. Treating pediatric patients with this disease process requires a deep understanding of its mechanism and treatment options. Advancements in medicine have provided alternatives for patients with chronic, debilitating disease, but further studies are still needed in hopes of prophylactic management.<\/jats:p>","DOI":"10.1002\/jpn3.70077","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:21:47Z","timestamp":1748226107000},"page":"304-313","source":"Crossref","is-referenced-by-count":3,"title":["The clinical course and management of pediatric chronic pancreatitis in the 21st century"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-6146","authenticated-orcid":false,"given":"Sherif Y.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center, MLC 2010 Cincinnati Ohio USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition MUSC Charleston South Carolina USA"},{"name":"Division of Gastroenterology and 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