{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:17:13Z","timestamp":1757780233091,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Graft versus host disease (GVHD) is a complication that frequently occurs after haematopoietic stem cell transplantation and concerns many children in paediatric haematology\u2010oncology and bone marrow transplantation departments. It can affect various organs, with the skin, gastrointestinal tract and liver being the most commonly involved. To confirm intestinal GVHD and to rule out differential diagnoses endoscopy is frequently needed. Currently, there are no specific consensus recommendations concerning the best method for endoscopic exploration and medical management of this disease in children, with limited studies available, including a low number of patients. Sigmoidoscopy could be initially proposed under sedation. If sigmoidoscopy is normal or if a general anaesthesia is required, colonoscopy and upper endoscopy should be planned, avoiding duodenal biopsy because of the risk of duodenal haematoma. Regarding therapeutic options, corticosteroids are the first\u2010line treatment for GVHD. Ruxolitinib, a Janus kinase inhibitor, is indicated for children aged 12 years and older with acute or chronic GVHD who have an inadequate response to corticosteroids or other systemic therapies. Nutritional support has a key role in the management of intestinal GVHD and should be considered to guarantee the best possible evolution of intestinal GVHD.<\/jats:p>","DOI":"10.1002\/jpn3.70087","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:19:19Z","timestamp":1748503159000},"page":"246-255","source":"Crossref","is-referenced-by-count":1,"title":["Intestinal involvement in graft versus host disease in children: An overview by the ESPGHAN Gastroenterology Committee"],"prefix":"10.1002","volume":"81","author":[{"given":"Marina","family":"Vincent","sequence":"first","affiliation":[{"name":"Department of Paediatric University Hospital Center Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Assa","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Centre The Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Division of Neurogastroenterology &amp; Motility, Department of Paediatric Gastroenterology Great Ormond Street Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matja\u017e","family":"Homan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Martin\u2010de\u2010Carpi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition Hospital Sant Joan de De\u0301u Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zrinjka","family":"Misak","sequence":"additional","affiliation":[{"name":"Referral Centre for Paediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Medical School University of Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giovanna","family":"Puoti","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Hepatology Santobono\u2010Pausilipon Hospital Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Scheers","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Cliniques universitaires Saint\u2010Luc Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sila","sequence":"additional","affiliation":[{"name":"Referral Centre for Paediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Medical School University of Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialist Surgery University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Tzivinikos","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Department, Al Jalila Children's Specialty Hospital Mohammed Bin Rashid University of Medicine and Health Sciences Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jernej","family":"Dolinsek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Centre Maribor, and Department of Pediatrics, Medical Faculty University of Maribor Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-7352","authenticated-orcid":false,"given":"Emmanuel","family":"Mas","sequence":"additional","affiliation":[{"name":"Service de Gastroente\u0301rologie, He\u0301patologie, Nutrition et Maladies He\u0301re\u0301ditaires du Me\u0301tabolisme, Ho\u0302pital des Enfants, and IRSD Universite\u0301 de Toulouse, INSERM, INRAE, ENVT, UPS Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw050"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.69"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01558-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702868"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000216"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422501"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0204-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0059"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001176"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2017.10.023"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PG9.0000000000000211"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.137"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.08.040"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000570"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001776"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31825048eb"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2016.19.1.29"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24634"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PG9.0000000000000163"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29235"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20924"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.01.034"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01639.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000609"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2507-x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2020.12.011"},{"key":"e_1_2_10_30_1","unstructured":"MalamutG. Les atrophies villositaires duod\u00e9nales non c\u0153liaques de l'adulte. 2022.https\/\/www.fmcgastro.org\/wp-content\/uploads\/2022\/03\/111_022_MALAMUT.pdf"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30256-X"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00342-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30061"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.06.008"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917635"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2033122"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/834168"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1002333"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2012.47.2.142"},{"key":"e_1_2_10_40_1","first-page":"S30","article-title":"Management of patients developing acute gastro\u2010intestinal graft\u2010versus\u2010host\u2010disease: guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM\u2010TC)","volume":"108","author":"Berranger E","year":"2021","journal-title":"Bull Cancer"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1075778"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2016.02.004"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000229419.73428.ff"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20700"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09114.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.220970"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:14:30Z","timestamp":1754032470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jpn3.70087"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70087","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"type":"print","value":"0277-2116"},{"type":"electronic","value":"1536-4801"}],"subject":[],"published":{"date-parts":[[2025,5,29]]}}}