{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:23:24Z","timestamp":1791602604242,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Introducing baked cow's milk and egg proteins to children with severe immunoglobulin E (IgE)\u2010mediated food allergies is controversial. This case series aimed to evaluate the safety and efficiency of the 5\u2010step milk ladder (5\u2010ML) and the 4\u2010step egg ladder (4\u2010EL) in a group of \u201chigh risk\u201d children with IgE\u2010mediated cow's milk (CMA) and hen's egg (HEA) allergies in the real\u2010life settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine children with IgE\u2010mediated CMA and\/or HEA, with a history of severe allergic symptoms and\/or asthma and\/or elevated specific IgE levels (defined as \u201chigh risk\u201d), were included. Tolerance acquisition to baked products was assessed via open\u2010label supervised oral food challenges (OFCs), subsequent steps of the food ladders were performed in the majority through home\u2010based reintroduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five out of 15 children (33%) developed tolerance to raw cow's milk proteins, while 11 children (73%) tolerated baked cow's milk (muffins). Three out of <jats:styled-content>23<\/jats:styled-content> children (13%) developed tolerance to any form of egg. Seventeen children (74%) tolerated baked egg in the form of muffins, 11 children (48%) tolerated pancakes, and 8 (35%) tolerated hard\u2010boiled egg or well\u2010cooked scrambled eggs. Tolerance loss occurred in two cases due to inconsistent introduction. In one case, parental concerns led to temporary withdrawal, but tolerance was reconfirmed. During OFCs, no anaphylaxis occurred; antihistamines were used in 10 children for minor reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case series provides evidence that assessing tolerance following the 5\u2010ML and 4\u2010EL in a \u201chigh\u2010risk\u201d group of children with IgE\u2010mediated food allergies is safe. However, regular monitoring of these children is essential.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70088","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:59:52Z","timestamp":1747889992000},"page":"331-338","source":"Crossref","is-referenced-by-count":5,"title":["Safety and effectiveness of milk and egg ladders in children with IgE\u2010mediated food allergy\u2014A case series"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1705-1205","authenticated-orcid":false,"given":"Daria","family":"Wiszniewska","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-0844","authenticated-orcid":false,"given":"Agata","family":"Str\u00f3\u017cyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-0001","authenticated-orcid":false,"given":"Andrea","family":"Horvath","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12630"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12801"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2023.100785"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12149"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-0898-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0281-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12283"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.043"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12958"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.036"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-23"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13714"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-022-00696-w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15061397"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114708"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00928.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100472"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-021-00583-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.09.029"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.04.057"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2024.1516774"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12705"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13372"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14081540"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:14:31Z","timestamp":1754032471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jpn3.70088"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70088","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}