{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:03:32Z","timestamp":1758819812533,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify and describe endoscopic and histological features of children with non\u2010monogenic very early\u2010onset inflammatory bowel diseases (VEO\u2010IBD) compared to endoscopic and histological features of children with later\u2010onset (LO\u2010IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective observational study in two Italian Pediatric IBD referral centers was done. Patients with VEO\u2010IBD were matched with LO\u2010IBD controls with a similar disease phenotype, with a 1:1 ratio for ulcerative colitis (UC) and 1:2 for Crohn's disease (CD). Clinical, endoscopic, and histological data were retrospectively collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three children with VEO\u2010IBD, 42 UC, 11 CD, and 68 with LO\u2010IBD (44 UC and 24 CD) were identified. Patients with VEO\u2010CD had more frequently isolated colonic disease compared to those with LO\u2010CD (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), whereas patients with VEO\u2010UC had more frequent pancolonic involvement (<jats:italic>p<\/jats:italic>\u2009=\u20090.05). As regards histologic findings, basal plasmacytosis intermingled with eosinophils, goblet cells depletion, active inflammation, and crypt architectural distortion were significantly more frequent in patients with LO\u2010UC compared to VEO\u2010UC (83.7% vs. 61.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.021, 100.0% vs. 73.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, 86.4% vs. 66.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.028), while in CD, skip lesions were more frequent in LO\u2010CD than in VEO\u2010CD (83.3% vs. 45.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VEO\u2010IBD and LO\u2010IBD exhibit different phenotypes with regard to disease localization and histological features. Younger children with UC exhibit a lower histological burden than those with LO\u2010UC, whereas typical characteristics of CD are rarely observed in VEO\u2010CD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70110","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T03:24:25Z","timestamp":1749612265000},"page":"286-294","source":"Crossref","is-referenced-by-count":1,"title":["Histological features of very early\u2010onset compared to later\u2010onset inflammatory bowel diseases: A multicenter retrospective study"],"prefix":"10.1002","volume":"81","author":[{"given":"Irene","family":"Dalpiaz","sequence":"first","affiliation":[{"name":"Gastroenterology and Nutrition Unit Meyer Children's Hospital IRCCS Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-4400","authenticated-orcid":false,"given":"Luca","family":"Scarallo","sequence":"additional","affiliation":[{"name":"Gastroenterology and 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