{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:08:12Z","timestamp":1754093292925,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of iron deficiency in predominantly breastfed infants at 6 months of age and compare the risk of iron deficiency between those born with latent iron deficiency (LID) and those with normal iron status (NIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study was conducted at a single tertiary care center in southern India. Infants born at a gestational age of more than 34 weeks were enrolled and classified based on their cord serum ferritin concentrations as having either NIS (ferritin\u2009&gt;\u200975\u2009ng\/mL) or LID (ferritin 11\u201375\u2009ng\/mL). At 6 months of age, these infants were reassessed for hemoglobin and serum ferritin levels to evaluate their iron status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 559 neonates included, 45 had LID and 514 had NIS at birth. At 6\u2010month follow\u2010up, 272 infants were reassessed: 33 with LID and 239 with NIS. The mean hemoglobin at 6 months was 10.21 (\u2009\u00b1\u20091.14) g\/dL in the LID group and 10.48 (\u2009\u00b1\u20090.96) g\/dL in the NIS group. The overall incidence of iron deficiency was 27.6%. The incidence was significantly higher in the LID group (48.5%) compared to the NIS group (24.7%), with a relative risk of 2.3 (95% CI: 1.48, 3.56), and a <jats:italic>p<\/jats:italic>\u2010value of\u2009&lt;\u20090.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Predominantly breastfed infants with LID at birth are at a significantly higher risk of developing iron deficiency by 6 months of age compared to those with NIS at birth. Early screening and timely iron supplementation in infants with LID may help mitigate iron deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70116","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T03:29:43Z","timestamp":1749612583000},"page":"324-330","source":"Crossref","is-referenced-by-count":0,"title":["Risk of iron deficiency at 6 months in predominantly breastfed infants with normal iron status and latent iron deficiency at birth"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1647-5089","authenticated-orcid":false,"given":"Puneeth Amaresh","family":"Babu","sequence":"first","affiliation":[{"name":"Department of Paediatrics Command Hospital Air Force Bangalore Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajoy Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Command Hospital Air Force Bangalore Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj Kumar","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Command Hospital Air Force Bangalore Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biju M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Command Hospital Air Force Bangalore Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1542\/peds.2010-2576","article-title":"Diagnosis and prevention of iron deficiency and iron\u2010deficiency anemia in infants and young children (0\u20133 Years of Age)","volume":"126","author":"Baker RD","year":"2010","journal-title":"Pediatrics"},{"issue":"5","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0022-3476(86)81041-1","article-title":"Cognitive deficits in iron\u2010deficient and iron\u2010deficient anemic children","volume":"108","author":"Deinard AS","year":"1986","journal-title":"J Pediatr"},{"issue":"3","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/ajcn\/68.3.683","article-title":"Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses","volume":"68","author":"Roncagliolo M","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_8_5_1","unstructured":"WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. 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