{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:16:25Z","timestamp":1781511385261,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pediatric inflammatory bowel disease (PIBD) incidence has increased in recent decades but may be stabilizing, prompting exploration of incidence changes, disease distribution, and severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2017 to 2019, patients under 18 years with PIBD symptoms were recruited from nine hospitals in South\u2010Eastern Norway for Inflammatory Bowel Disease in South\u2010Eastern Norway III (IBSEN III), a population\u2010based inception cohort study. The primary outcome was a diagnosis of any PIBD subtype as defined by revised Porto criteria. Paris classification system defined disease phenotypes, and descriptions of covariates were gathered from patients in IBSEN III.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 324 PIBD patients, with 216 consenting to the IBSEN III study. The crude incidence rate was 17.8 per 100,000 person\u2010years (PY) (95% confidence interval [CI]: 15.9\u201319.8). Crohn's disease (CD) was found in 118 patients (54.6%); 48% had ileocolonic distribution, 40% had upper gastrointestinal disease, and 12.8% had perianal disease. Complications (stricturing and\/or penetrating) were noted in 18%. Ulcerative colitis (UC) was diagnosed in 78 patients (36.1%), predominantly pancolitis (41%), with 30% having proctitis. One in five suffered severe disease. IBD unclassified was found in 20 patients (9.3%). PIBD incidence in those under 16 was 13.6\/100,000 PY, up from 4.7 in the IBSEN study 27 years ago. Terminal ileitis (11%\u201323%) and proctitis (14%\u201325%) rose from IBSEN (1990\u20131993) to IBSEN III, while stricturing\/penetrating disease changed insignificantly (17%\u201316%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of PIBD has risen in South\u2010Eastern Norway, with increased cases of terminal ileitis in CD, unchanged stricturing\/penetrating disease, and increased proctitis in UC compared to the original IBSEN study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT02727959.\n                    <\/jats:p>\n        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Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Opheim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Oslo University Hospital Oslo Norway"},{"name":"Department of Public Health Science Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Olbj\u00f8rn","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Rove","sequence":"additional","affiliation":[{"name":"Pediatric Department Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"L\u00f8vlund","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine \u00d8stfold Hospital Trust Gr\u00e5lum 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