{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:16:37Z","timestamp":1785550597057,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Antitumor necrosis factor (anti\u2010TNF) therapies are first\u2010line therapies for children with inflammatory bowel disease (IBD) (Crohn's disease [CD], ulcerative colitis [UC] and IBD\u2010unclassified [IBD\u2010U]). Limited studies describing anti\u2010TNFs durability and loss of response in children. This study evaluates predictors of primary Nonresponse and 3\u2010year drug durability in children with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center retrospective review of patients with IBD less than 18 years old who initiated anti\u2010TNF (infliximab or adalimumab) from January 1, 2014, to December 31, 2019. Clinical and laboratory data were recorded at the time of anti\u2010TNF initiation, 14 weeks, 12 months, and 3 years. Predictors of primary nonresponse (discontinuation within 14 weeks) and durability were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 456 patients initiated anti\u2010TNF therapy (183 adalimumab and 273 infliximab). Thirty\u2010seven (8%) patients were primary nonresponders. The 3\u2010year drug durability for both therapies was &gt;70%. Among patients with CD, the 3\u2010year durability was &gt;75% for both therapies. The 3\u2010year durability with UC\/IBD\u2010U was 37% for adalimumab and 56% for infliximab. Predictors of primary nonresponse were an erythrocyte sedimentation rate\u2009&gt;\u200955\u2009mm\/h in CD on infliximab, and baseline albumin &lt;4\u2009g\/dL and &lt;15.6 years at diagnosis in UC\/IBD\u2010U.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010TNF therapies had a 3\u2010year durability of &gt;75% in patients with CD, while the durability was lower (37%\u201356%) for patients with UC\/IBD\u2010U. Less than 10% of patients were considered primary nonresponders, which lends support to the long\u2010term durability of anti\u2010TNF therapies for pediatric IBD while keeping in mind predictive factors of Nonresponse.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.70160","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T09:14:37Z","timestamp":1753089277000},"page":"1024-1033","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of antitumor necrosis factor primary nonresponse and drug durability in pediatric inflammatory bowel disease"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-9259","authenticated-orcid":false,"given":"Nicole","family":"Davidson","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant 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