{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:11:08Z","timestamp":1791576668643,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ustekinumab, a monoclonal antibody used in adults, is increasingly employed in children and adolescents with refractory inflammatory bowel disease (IBD). This review aimed to analyze its long\u2010term efficacy and safety in the pediatric population. To this end, a systematic review was registered under PROSPERO (CRD42024555896). Articles indexed in PubMed\/Medline, Cochrane Library, and Web of Science up to May 30, 2024, were screened. Quality was assessed using the Newcastle\u2013Ottawa Scale. From 563 articles, 11 observational studies were included, analyzing 444 pediatric IBD patients. Remission rates varied: 47% at Week 16, 57%\u201359% at Week 26, and 40%\u201364% at Week 52. In addition, clinical improvements included better\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010scores, body mass index, reduced inflammation, and healing of mucosal and perianal disease. Five studies standardized doses by weight: 260\u2009mg (&lt;55\u2009kg), 390\u2009mg (55\u201385\u2009kg), and 520\u2009mg (&gt;85\u2009kg), with maintenance doses typically 90\u2009mg every 8\u201312 weeks. Some patients received concomitant therapies (e.g., methotrexate, corticosteroids, and 5\u2010aminosalicylic acid). While adverse effects were reported, including worsening psoriasis, cutaneous and neurological reactions, infections, elevated transaminases, and lymphopenia. Severe adverse events were rare, though anaphylaxis and one death from acute diarrhea were reported. Overall, ustekinumab shows promising clinical and laboratory outcomes in pediatric IBD. However, long\u2010term studies are essential to solidify evidence regarding remission rates and adverse effects.\n                  <\/jats:p>","DOI":"10.1002\/jpn3.70163","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T03:58:22Z","timestamp":1753329502000},"page":"1045-1059","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term effects of ustekinumab in children with inflammatory bowel disease: A systematic review"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-6741","authenticated-orcid":false,"given":"Breno Oliveira","family":"Marques","sequence":"first","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7218-5505","authenticated-orcid":false,"given":"Ana Beatriz Ferreira","family":"Gusm\u00e3o","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-5935","authenticated-orcid":false,"given":"Ana Luiza Ferreira","family":"Gusm\u00e3o","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3841-5404","authenticated-orcid":false,"given":"Bianca Ferraz de Almeida","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-3875","authenticated-orcid":false,"given":"Gabrielle Silva","family":"Sousa","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9463-6523","authenticated-orcid":false,"given":"Jessica Sabrina Gon\u00e7alves","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-7630","authenticated-orcid":false,"given":"Nikolas Brayan da Silva","family":"Bragas","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-7509","authenticated-orcid":false,"given":"Natalia Oliveira e","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Vit\u00f3ria da Conquista Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2021.05.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2023.05.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2023.05.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2024.151398"},{"issue":"5","key":"e_1_2_7_6_1","article-title":"Ustekinumab in the treatment of inflammatory bowel diseases: evolving paradigms","volume":"13","author":"Mocci G","year":"2024","journal-title":"J Clin Med Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2022.00007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058037"},{"key":"e_1_2_7_9_1","unstructured":"PROSPERO [Internet].https:\/\/www.crd.york.ac.uk\/prospero\/"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-265x-tce-2017-0279"},{"key":"e_1_2_7_12_1","unstructured":"ShanaaA. Rayyan\u2014Intelligent Systematic Review. Rayyan. 2021."},{"key":"e_1_2_7_13_1","unstructured":"Ottawa Hospital Research Institute [Internet].https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy206"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002362"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2019.09164"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16388"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003230"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15128"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003608"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-024-00631-z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_7_24"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1371322"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05588-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12169"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab185"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S433636"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-020-00773-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-023-00586-7"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02280-3"},{"key":"e_1_2_7_31_1","unstructured":"Annex I Summary of Product Characteristics STELARA [Internet].https:\/\/ec.europa.eu\/health\/documents\/community-register\/2018\/20180130140005\/anx_140005_pt.pdf"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac055"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2023.00091"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.043"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz119"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:22:00Z","timestamp":1759292520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jpn3.70163"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70163","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]}}}