{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:33Z","timestamp":1786978113729,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether the prognosis of pediatric\u2010onset inflammatory bowel disease (IBD) is influenced by its association with primary sclerosing cholangitis (PSC) considering medical treatment, bowel resection, risk of cancer, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective population\u2010based study was conducted using data from the EPIMAD Registry, one of the most extensive prospective population\u2010based IBD studies globally. Cases (IBD\u2010PSC) were compared with matched controls (matched\u2010IBD). Inclusion criteria were age \u226417 years at IBD diagnosis and follow\u2010up \u22652 years. PSC was confirmed by magnetic resonance cholangiopancreatography and\/or histology. Each case was matched to four controls by propensity score (i.e., sex, age, year, and location of IBD at diagnosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 24 cases and 96 controls. Median duration of follow\u2010up was 6.4 years (interquartile range\u2009=\u20093.1\u201314.3). No significant difference was observed between the two groups in terms of exposure to treatment at 5 years (immunosuppressants, corticosteroids, or antitumor necrosis factor). In IBD\u2010PSC, cancers were 28 times more frequent (standardized incidence ratio\u2009=\u200927.9; 95% confidence interval [CI], 7.0\u2013111.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and death was 13 times more frequent (standardized mortality ratio\u2009=\u200913.3; 95% CI, 3.3\u201353.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) than in the general population. No increased risk of cancer or mortality was observed in patients with IBD but without PSC compared to the general population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the course of IBD is not different, the prognosis of pediatric\u2010onset IBD associated with PSC is significantly worse than that of pediatric\u2010onset IBD without PSC because of increased cancer and mortality rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70176","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T04:21:17Z","timestamp":1755058877000},"page":"1180-1188","source":"Crossref","is-referenced-by-count":2,"title":["Prognosis of pediatric\u2010onset inflammatory bowel disease associated with primary sclerosing cholangitis: A population\u2010based study"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-8298","authenticated-orcid":false,"given":"Marie\u2010Laura","family":"Godet","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology, and Nutrition Unit, Department of Pediatrics CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Sarter","sequence":"additional","affiliation":[{"name":"U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille Lille France"},{"name":"Public Health, Epidemiology and Economic Health Unit Epimad Registry, Maison R\u00e9gionale de la Recherche Clinique, CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Gottrand","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology, and Nutrition Unit, Department of Pediatrics CHU Lille Lille France"},{"name":"U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Saoudi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology, and Nutrition Unit, Department of Pediatrics CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Univ. Lille, Inserm, CHU Lille, U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Amiens University Hospital, and Peritox, UMRI01 Universit\u00e9 de Picardie Jules Verne Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Savoye","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Rouen University Hospital, UMR 1073 University of Rouen Normandy Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Leroyer","sequence":"additional","affiliation":[{"name":"U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille Lille France"},{"name":"Public Health, Epidemiology and Economic Health Unit Epimad Registry, Maison R\u00e9gionale de la Recherche Clinique, CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Gower\u2010Rousseau","sequence":"additional","affiliation":[{"name":"Research Unit and Public Health, Reims University Hospital Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Ley","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology, and Nutrition Unit, Department of Pediatrics CHU Lille Lille France"},{"name":"U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Univ. 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