{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:07:09Z","timestamp":1784826429421,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hepatic steatosis has been described in children with severe acute malnutrition, but the degree of liver damage in children with moderate acute malnutrition (MAM) is unknown. This study aimed to investigate the development of malnutrition\u2010associated liver damage by describing liver function tests among children with MAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a randomized 2\u2009\u00d7\u20092\u2009\u00d7\u20093 factorial trial, Treatfood, conducted in Burkina Faso. Children (6\u201323 months) with MAM received either a lipid\u2010based nutrient supplement or a corn\u2010soy blend, containing either dehulled soy or soy isolate and different quantities of dried skim milk. Malaria rapid diagnostic tests and liver function tests were performed at inclusion and after 3 months of supplementation and compared to Danish reference intervals. Associations were analyzed with linear regressions or tobit regressions, and odds ratios were calculated with logistic regressions, all age\u2010 and sex\u2010adjusted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 1405 children had one or more liver function tests measured at baseline. The median age was 11.4 months [interquartile range: 8.2\u201316.1]. Few children had elevated concentrations of liver function tests at baseline. Concentrations of total bilirubin were 19% (95% confidence interval: 2\u201340) greater among children with length\u2010for\u2010age\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores &lt;\u22123 compared with children with\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores \u2265\u22122. The concentrations of total bilirubin and alkaline phosphatase were negatively associated with age. Minor changes in the serum concentrations of liver function tests were observed after intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Liver function tests were largely within the normal range, whereby no signs of manifest liver damage were found. Children with stunted growth had higher bilirubin, which might indicate subclinical liver damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>ISRCTN number: ISRCTN42569496<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70177","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:58:38Z","timestamp":1755064718000},"page":"1280-1286","source":"Crossref","is-referenced-by-count":2,"title":["Liver function tests among children with moderate acute malnutrition: A secondary analysis of a randomized trial from Burkina Faso"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-0369","authenticated-orcid":false,"given":"Christina L.","family":"Winther","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thora W.","family":"Helt","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fabiansen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Frikke\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Filteau","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Briend","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"},{"name":"Center for Child Health Research Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim F.","family":"Michaelsen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"M\u00e9decins Sans Fronti\u00e8res\u2010Denmark Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"UNICEF (United Nations Children's Fund). Child Malnutrition [Internet]. 2023.https:\/\/data.unicef.org\/topic\/nutrition\/malnutrition\/"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization. Malnutrition. 2024.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malnutrition\/"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.11.1348"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050653"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104702"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002387"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.11.3127"},{"key":"e_1_2_9_9_1","unstructured":"RH Laboratorieunders\u00f8gelse [Internet].https:\/\/labportal.rh.dk\/Labportal.asp?ShowStart=Y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155143"},{"key":"e_1_2_9_11_1","article-title":"Prognostic significance of serum biochemistry profile in children with severe acute malnutrition","volume":"14","author":"Verma GK","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40795-016-0096-0"},{"key":"e_1_2_9_13_1","volume-title":"StatPearls [Internet]","author":"Lowe D","year":"2024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-022-01039-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1111445"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00729-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0098"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4018"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-016-0127-x"},{"issue":"7","key":"e_1_2_9_21_1","first-page":"107","article-title":"Refeeding syndrome","volume":"120","author":"Heuft L","year":"2023","journal-title":"Dtsch Arzteblatt Int"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0821-0"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:34:54Z","timestamp":1780025694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpn3.70177"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70177","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}