{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:44:52Z","timestamp":1791546292454,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Autoimmune gastritis (AIG) has been poorly described in childhood. We sought to identify the patterns of manifestations of pediatric AIG at onset and to describe its laboratory, clinical, and histopathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective, longitudinal, multicenter, cohort study enrolling histologically proven AIG patients with an onset in the pediatric age (&lt;18 years old). We retrieved laboratory and clinical data at the time of onset and at last follow\u2010up when available. Differences between\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      \u2010exposed versus\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010na\u00efve, and anti\u2010parietal cell antibody (PCA)\u2010positive versus PCA\u2010negative patients were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 51 pediatric AIG patients (median age: 13 years, interquartile range: 11\u201316; F:M ratio 1.7:1) were included. Most patients were diagnosed with the overt type of AIG (47; 92.1%), while four (7.8%) were still in the potential phase. Atopic dermatitis (9.8%), rhinitis (7.8%), and asthma (5.9%) were common comorbidities, suggesting a link with T helper 2 (Th2) disorders. Two patients (3.9%) were found to have had previous or concurrent eosinophilic esophagitis, and five (9.8%) had eosinophilic gastritis. Notably, four patients (7.8%) presented with collagenous gastritis. On histological examination, the majority of patients were negative for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection, except for 1 case out of 51 (2.0%) who had an active infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AIG may affect pediatric patients and lead to complications in this population. At presentation, the disease may exhibit histologic patterns attributed to collagenous and\/or eosinophilic gastritis. Moreover, a possible association between AIG and Th2 disorders has been observed, warranting further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70187","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:54:46Z","timestamp":1755064486000},"page":"1142-1150","source":"Crossref","is-referenced-by-count":13,"title":["Pediatric autoimmune gastritis: An international, multicentric study"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-4911","authenticated-orcid":false,"given":"Marco Vincenzo","family":"Lenti","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Therapeutics University of Pavia Pavia Italy"},{"name":"First Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamim","family":"Joudaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapeutics University of Pavia Pavia Italy"},{"name":"First Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Miceli","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine, Sant'Andrea Hospital Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Massironi","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Istituti Ospedalieri Bergamaschi Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Votto","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia Pavia Italy"},{"name":"Pediatric Clinic Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Licari","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia Pavia Italy"},{"name":"Pediatric Clinic Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Maria Elena","family":"Caimmi","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia Pavia Italy"},{"name":"Pediatric Clinic Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bramuzzo","sequence":"additional","affiliation":[{"name":"Pediatric Department Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Pediatric Department Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Crocco","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Malerba","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Child and Maternal Health University of Genoa Genoa Italy"},{"name":"UOC Pediatria e neonatologia Gaslini Imperia Imperia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggiero","family":"Francavilla","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, Pediatric Section, Children's Hospital \u2018Giovanni XXIII\u2019 University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Lionetti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit Meyer Children's Hospital, IRCCS Florence Italy"},{"name":"Department of NEUROFARBA University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Alvisi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Maggiore \u201cCA Pizzardi\u201d Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Panceri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fondazione IRCCS San Gerardo dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zuin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fondazione IRCCS San Gerardo dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[{"name":"Institute of Pathology ASST\u2010Spedali Civili University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Barp","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit Meyer Children's Hospital, IRCCS Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fuoti","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and GI Endoscopy Unit, Children's Hospital ASST Spedali Civili University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Oliva","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department University Hospital \u2013 Umberto I Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Aloi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit Umberto I Hospital Rome Italy"},{"name":"Pediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Distante","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Assa","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center Jerusalem Israel"},{"name":"The Faculty of Medicine The Hebrew University of Jerusalem Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogev","family":"Dotan","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center Jerusalem Israel"},{"name":"The Faculty of Medicine The Hebrew University of Jerusalem Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Amato","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy and Gastroenterology Unit ASST Lecco Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Romano","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood \u201cG. Barresi\u201d University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Staiano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics, University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmo","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics, University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Women, Child and General and Specialist Surgery University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Fioretti","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics, University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Zingone","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology, and Gastroenterology University of Padua Padua Italy"},{"name":"Gastroenterology Unit Azienda Ospedale Universit\u00e0 di Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Cananzi","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Gastroenterology, Digestive Endoscopy, Hepatology and Care of the Child with Liver Transplantation, Department for Women's and Children's Health University Hospital of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"De Giacomo","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Mother and Child Health ASST Grande Ospedale Metropolitano Niguarda Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Quadrelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapeutics University of Pavia Pavia Italy"},{"name":"First Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Vanoli","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology, Department of Molecular Medicine University of Pavia Pavia Italy"},{"name":"Unit of Anatomic Pathology Fondazione IRCCS San Matteo Hospital Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Paulli","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology, Department of Molecular Medicine University of Pavia Pavia Italy"},{"name":"Unit of Anatomic Pathology Fondazione IRCCS San Matteo Hospital Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine, Sant'Andrea Hospital Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Marseglia","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia Pavia Italy"},{"name":"Pediatric Clinic Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-8645","authenticated-orcid":false,"given":"Antonio","family":"Di Sabatino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapeutics University of Pavia Pavia Italy"},{"name":"First Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0187-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1070250"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.08.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0901-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112113"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15317"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002948"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21187"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12318"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002547"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.07.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i42.15780"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00123"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031597"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103437"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.5671"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031062"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v15.i8.1451"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.10.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103143"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-331164"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12112784"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.04.015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-2-17"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.910077"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031062"},{"key":"e_1_2_8_29_1","article-title":"Collagenous gastritis: an atypical presentation of a rare disease","volume":"15","author":"Kagihara JE","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.04.013"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000510"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:33:57Z","timestamp":1780025637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpn3.70187"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70187","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}