{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:03:21Z","timestamp":1780027401944,"version":"3.53.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Exocrine pancreatic insufficiency (EPI) results from insufficient pancreatic enzyme and bicarbonate production, impairing digestion and causing malnutrition. Limited studies have been conducted to fully understand the underlying mechanisms contributing to pediatric EPI. The aim of this study was to measure interleukin\u20108 (IL\u20108) levels in pancreatic fluid of EPI patients to determine if IL\u20108 could be an inflammatory mediator in pediatric EPI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, IL\u20108 protein levels were measured in pancreatic fluid collected from 193 pediatric patients evaluated for EPI. Based on the endoscopic pancreatic function test (ePFT) results, patients were categorized into normal and EPI groups, and statistical analyses explored associations between IL\u20108, enzyme deficiency, symptoms, and clinical diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u20108 levels were elevated in EPI patients (30%), versus normal group (6%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Symptoms significantly associated with EPI were constipation, diarrhea and weight loss. However, it is important to note that many of these symptoms overlapped with other symptoms. No significant association was observed between IL\u20108 and the disease subgroups, except for disaccharidase deficiency. Overall, there was a strong association of IL\u20108 with pancreatic enzyme deficiency, suggesting its role in EPI pathogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study to measure IL\u20108 levels in pancreatic fluid of a large cohort of pediatric EPI patients. The elevated IL\u20108 levels suggest its potential role as an inflammatory mediator in pediatric EPI. Furthermore, these findings open avenues for investigating other inflammatory factors that may contribute to EPI development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70192","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:46:14Z","timestamp":1755063974000},"page":"1271-1279","source":"Crossref","is-referenced-by-count":0,"title":["Elevated interleukin\u20108 in pancreatic fluid of pediatric patients with exocrine pancreatic insufficiency"],"prefix":"10.1002","volume":"81","author":[{"given":"Arun","family":"Ajmera","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3582-2546","authenticated-orcid":false,"given":"Nidhi","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samit","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirajyoti","family":"Deb","sequence":"additional","affiliation":[{"name":"Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Abomoelak","sequence":"additional","affiliation":[{"name":"Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Schreck","sequence":"additional","affiliation":[{"name":"Orlando Health Medical Group Pediatric Specialty Practice Resources Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Orlando Health Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","article-title":"Management of exocrine pancreatic insufficiency in children","volume":"34","author":"Sankararaman S","year":"2019","journal-title":"Nutr Clin Pract"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245779"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002931"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001540"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02606-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137177"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)00240-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.04.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114265"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i10.1123"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i15.1845"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.3.423"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.June.18.6"},{"issue":"3","key":"e_1_2_8_16_1","first-page":"138","article-title":"Expression of interleukin\u20108 in human obstructive pancreatitis","volume":"5","author":"Motoo Y","year":"2004","journal-title":"JOP: J Pancreas"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200309000-00013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-114"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(01)00016-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i35.3957"},{"key":"e_1_2_8_21_1","unstructured":"TeamRC.R: A Language and Environment for Statistical Computing.Foundation for Statistical Computing.2013."},{"key":"e_1_2_8_22_1","unstructured":"RichB Tables of Descriptive Statistics in HTML.2023."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S402589"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31820b0227"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.908542"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01826.x"},{"issue":"4","key":"e_1_2_8_27_1","first-page":"765","article-title":"Potential involvement of IL\u20108 and its receptors in the invasiveness of pancreatic cancer cells","volume":"22","author":"Kuwada Y","year":"2003","journal-title":"Int J Oncol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24040"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13885"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02063235"},{"issue":"2","key":"e_1_2_8_31_1","first-page":"201","article-title":"The potential molecular mechanism of overexpression of uPA, IL\u20108, MMP\u20107 and MMP\u20109 induced by TRAIL in pancreatic cancer cell","volume":"7","author":"Zhou DH","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.026"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010162"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9852-y"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094564"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1121-421X.19.02636-9"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003725"},{"issue":"5","key":"e_1_2_8_38_1","first-page":"997","article-title":"Expression of interleukin\u20108 gene in inflammatory bowel disease is related to the histological grade of active inflammation","volume":"144","author":"Mazzucchelli L","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03188-w"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2020.tb00108.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2172671"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8538"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.535"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30082"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.36830"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32409"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374017"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104089"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.05.024"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:34:34Z","timestamp":1780025674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpn3.70192"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70192","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}