{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:33Z","timestamp":1786978113594,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the best cut\u2010off of alanine aminotransferase (ALT) to predict the metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in youths with overweight\/obesity (OW\/OB) and analyze the performance of the triglyceride\u2010glucose index (TyG) or its association with anthropometric variables compared to ALT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter, cross\u2010sectional study analyzed data of 2813 youths (1463 boys and 1350 girls) aged 6\u201317 years recruited in 10 Italian centers for the management of pediatric OB. Exclusion criteria were: body mass index (BMI)\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score &gt;5, diabetes, secondary obesity, triglycerides (TG)\u2009\u2265\u2009400\u2009mg\/dL. MASLD was defined on the presence of hepatic steatosis at abdominal ultrasound, in combination with at least one cardiometabolic risk factor. The performance of ALT and TyG\u2010derived indices for MASLD diagnosis was assessed using the receiver operation curve and the area under the curve (AUC) with the 95% confidence intervals were obtained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MASLD was observed in 1278 youths (45.1%). The global AUC of ALT was 0.661 (0.641\u20130.682),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001. Using Youden's index the best cut\u2010off of ALT was \u226526\u2009IU\/L in boys and \u226522\u2009IU\/L in girls. The AUCs of TyG\u2010BMI, TyG\u2010WC, and TyG\u2010ALT were 0.678 (0.659\u20130.698), 0.659 (0.639\u20130.679), and 0.666 (0.645\u20130.686), respectively. Using Delong's test none TyG\u2010derived index showed a better performance than ALT alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that the values of ALT\u2009\u2265\u200926\u2009IU\/L in boys and \u226522\u2009IU\/L in girls can be used for the screening of MASLD in youths with OW\/OB, while the combination of TyG\u2010derived indices is not superior to ALT alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70201","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:10:14Z","timestamp":1755861014000},"page":"1287-1295","source":"Crossref","is-referenced-by-count":5,"title":["Ability of triglyceride\u2010glucose indices to predict metabolic dysfunction associated with steatotic liver disease in pediatric obesity"],"prefix":"10.1002","volume":"81","author":[{"given":"Procolo","family":"Di Bonito","sequence":"first","affiliation":[{"name":"Department of Internal Medicine \u201cS. Maria delle Grazie\u201d Hospital Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Sessa","sequence":"additional","affiliation":[{"name":"Department of the Woman, the Child and General and Specialized Surgery University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Licenziati","sequence":"additional","affiliation":[{"name":"Neuro\u2010Endocrine Diseases and Obesity Unit, Department of Neurosciences Santobono\u2010Pausilipon Children's Hospital Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Corica","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood \u201cG. Barresi\u201d, Pediatric Unit University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata Gabriela","family":"Wasniewska","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood \u201cG. Barresi\u201d, Pediatric Unit University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Morandi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism University and University Hospital of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Maffeis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism University and University Hospital of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Felicia","family":"Faienza","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area University of Bari \u201cA. Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Mozzillo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics University of Napoli \u201cFederico II\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Calcaterra","sequence":"additional","affiliation":[{"name":"Pediatric Department, \u201cV. Buzzi\u201d Children's Hospital, Milano and Department of Internal Medicine University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Franco","sequence":"additional","affiliation":[{"name":"Pediatric Department Azienda Sanitaria Universitaria del Friuli Centrale, Hospital of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Maltoni","sequence":"additional","affiliation":[{"name":"Pediatric Unit, IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[{"name":"Department of the Woman, the Child and General and Specialized Surgery University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina Rosaria","family":"Umano","sequence":"additional","affiliation":[{"name":"Department of the Woman, the Child and General and Specialized Surgery University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5063-4333","authenticated-orcid":false,"given":"Giuliana","family":"Valerio","sequence":"additional","affiliation":[{"name":"Department of Medical, Movement and Wellbeing Sciences University of Napoli \u201cParthenope\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00047-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00435-4"},{"key":"#cr-split#-e_1_2_7_4_1.1","unstructured":"WHO Federation.World Obesity Atlas 2023"},{"key":"#cr-split#-e_1_2_7_4_1.2","unstructured":"2023. Accessed 6 March 2025.https:\/\/data.worldobesity.org\/publications\/?cat=19"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.11.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318063"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-024-00814-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100685"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2015.10.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12156"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05848-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-331090"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001482"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12518"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.06.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.09.033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318252a13f"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14234969"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.11.042"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038241"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0525-6"},{"key":"e_1_2_7_23_1","unstructured":"Accessed March 31 2025.https:\/\/www.who.int\/tools\/growth-reference-data-for-5to19-years\/application-tools"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2504141"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.021"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1043169"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-84809-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1188214"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1124019"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-024-10660-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S500042"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070189"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2023.102137"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-02054-5"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02241-y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2022.07.024"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1788501"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12303"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.052"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz010"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:33:21Z","timestamp":1780025601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpn3.70201"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70201","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}