{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:48:20Z","timestamp":1764611300492,"version":"3.46.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diagnosing celiac disease (CD) via esophagogastroduodenoscopy (EGDS) is necessary when anti\u2010transglutaminase (anti\u2010TG) antibody levels are below 10\u00d7 the upper limit of normal (ULN). This study evaluates patients with low anti\u2010TG titers, particularly when endomysial antibodies (EMA) are negative. In this retrospective study (2022\u20132024), patients undergoing EGDS for suspected CD were grouped by EMA status: Group 1 (EMA negative) and Group 2 (EMA positive), with similar low anti\u2010TG titers. Group 1 (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200925) had a mean anti\u2010TG titer of 1.86\u00d7 ULN and villous atrophy (VA) in only 8% (2\/25). Group 2 (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009100) had VA in 35% (35\/100), a 6.16\u2010fold higher risk. Nonatrophic cases showed no significant histological and immunohistochemical differences. In conclusion, low\u2010titer anti\u2010TG with negative EMA indicates a low likelihood of VA. Most asymptomatic patients may not require immediate intervention but should be monitored. EGDS can be reserved to later stages if clinical suspicion persists.\n                  <\/jats:p>","DOI":"10.1002\/jpn3.70214","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T07:53:14Z","timestamp":1759477994000},"page":"1482-1487","source":"Crossref","is-referenced-by-count":0,"title":["Advantages of anti\u2010endomysial evaluation in children with low titers of anti\u2010transglutaminase antibodies: A retrospective study"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1806-0147","authenticated-orcid":false,"given":"Roberta","family":"Mandile","sequence":"first","affiliation":[{"name":"European Laboratory for Food Induced Disease (ELFID) University Federico II of Naples Naples Italy"},{"name":"Department of Translational Medical Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pia","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariantonia","family":"Maglio","sequence":"additional","affiliation":[{"name":"European Laboratory for Food Induced Disease (ELFID) University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Troncone","sequence":"additional","affiliation":[{"name":"European Laboratory for Food Induced Disease (ELFID) University Federico II of Naples Naples Italy"},{"name":"Department of Translational Medical Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Auricchio","sequence":"additional","affiliation":[{"name":"European Laboratory for Food Induced Disease (ELFID) University Federico II of Naples Naples Italy"},{"name":"Department of Translational Medical Sciences University Federico II of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.6.851"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"141","article-title":"Anti\u2010endomysium antibodies detection in 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effect of gluten free diet on clinical symptoms and the intestinal mucosa of patients with potential celiac disease","volume":"66","author":"Mandile R","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16111708"}],"container-title":["Journal of Pediatric Gastroenterology and 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