{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:48:19Z","timestamp":1764611299734,"version":"3.46.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We prospectively evaluated the interpretability, diagnostic yield, and tolerance of high\u2010resolution (impedance\u2010) manometry, 24\u2009h\u2010pH\u2010impedance and pH\u2010MII with manometry (two catheters) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All children who underwent testing were eligible. We assessed whether the results explained the patients' symptoms (interpretability) and recorded the diagnostic yield of each test. A validated questionnaire (DISCOmfort in Research with Children [DISCO\u2010RC]) was additionally used to measure discomfort during the procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine HR(I)M, 35 pH\u2010MII, and 9 pH\u2010MII\u2009+\u2009mano were performed in 62 children (median age: 13 [0\u201318] years). Nine (25%) pH\u2010MII catheters were placed under sedation during another procedure. Seven (7.4%) tests (five h(I)M and two pH\u2010MII) were uninterpretable. All\n                      <jats:italic>normal<\/jats:italic>\n                      tests were considered clinically helpful by the attending physician. Sixty\u2010nine (74.2%) tests in 58 patients (93.5%) led to clinical management that would likely not have occurred without testing. DISCO\u2010RC scores were 7.0 (1\u201317), 6.0 (01\u201319), and 14.0 [9\u201317] in HR(I)M, pH\u2010MII, and pH\u2010MII\u2009+\u2009mano, respectively. DISCO\u2010RC scores were significantly higher in pH\u2010MII\u2009+\u2009mano (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) compared to HR(I)M and pH\u2010MII respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HR(I)M, pH\u2010MII, and pH\u2010MII\u2009+\u2009mano are interpretable and clinically useful in most children. HR(I)M and pH\u2010MII are reasonably well tolerated, whereas adding ambulatory manometry causes more discomfort and should be reserved for cases where the diagnosis of rumination cannot be made without it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70217","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T04:37:34Z","timestamp":1759811854000},"page":"1496-1506","source":"Crossref","is-referenced-by-count":0,"title":["Prospective evaluation of the diagnostic yield and tolerance of high\u2010resolution manometry, pH\u2010impedance, and pH\u2010impedance\u2010manometry"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-5331","authenticated-orcid":false,"given":"Carlijn M.","family":"Mussies","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinde","family":"van Lennep","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jac M.","family":"Oors","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel P.","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.048"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14250"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001401"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2022.25.4.300"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002232"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0949-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91428-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(18)30071-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-17"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182868773"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2008.04.035"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doaf022"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04315-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000571"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_AJSLP-18-0039"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182952e50"},{"key":"e_1_2_8_21_1","first-page":"33","volume-title":"Pediatric Neurogastroenterology","author":"Wijk MV","year":"2023"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:44:39Z","timestamp":1764611079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jpn3.70217"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70217","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"type":"print","value":"0277-2116"},{"type":"electronic","value":"1536-4801"}],"subject":[],"published":{"date-parts":[[2025,10,6]]}}}