{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:43:54Z","timestamp":1776401034711,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Celiac disease (CeD) is a life\u2010long systemic immune\u2010mediated disorder. Data on burden and cost of CeD in children are scarce. We assessed healthcare resource utilization (HCRU) and cost of healthcare services of newly diagnosed children in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2010control study covered a period from 2014 to 2021, using German Statutory Health Insurance claims data from the \u201cInstitute for Applied Health Research Berlin\u201d (InGef). The HCRU (hospitalizations, outpatient contacts, outpatient drug prescriptions) and cost of CeD patients aged &lt;6 (group 1) and 6\u201311 years (group 2) between 2017 and 2019 were compared with matched non\u2010CeD individuals (1:5 matching by age, sex, Charlson Comorbidity Index, and region) during the time of diagnosis and 2 years thereafter. Case definition required \u22651 diagnosis of CeD (ICD\u201010\u2010GM K90.0) as inpatient or \u22652 recorded diagnoses as outpatient plus \u22651 CeD\u2010related serological test, and no recorded CeD diagnoses during the 3\u2010year preobservation period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 410 CeD cases resulting in incidence rates of 32.5 and 34.1 per 100,000 individuals in groups 1 and 2, respectively. During time of diagnosis and 2 years thereafter, CeD patients had increased HCRU (median) compared to their controls (two more hospitalizations, almost three\u2010times more outpatient contacts, and 3\u20134 more prescriptions), resulting in higher total costs (median difference \u20ac1677 and \u20ac1343 in group 1 and 2, respectively) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings underscore the substantial burden of CeD on patients and healthcare systems, highlighting the need for targeted interventions and effective management strategies to mitigate this impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70236","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:23:44Z","timestamp":1760700224000},"page":"118-128","source":"Crossref","is-referenced-by-count":0,"title":["Healthcare resource utilization and cost in pediatric celiac disease: A case\u2010control study using German insurance data"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2374-8778","authenticated-orcid":false,"given":"Sibylle","family":"Koletzko","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dr. von Hauner Children\u2032s Hospital LMU University Hospital Munich Munich Germany"},{"name":"Department of Pediatrics, Gastroenterology and Nutrition School of Medicine Collegium Medicum University of Warmia and Mazury Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4735-5418","authenticated-orcid":false,"given":"Svitlana","family":"Schnaidt","sequence":"additional","affiliation":[{"name":"EU Real World Evidence, PharmaLex GmbH, part of Cencora Inc Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-046X","authenticated-orcid":false,"given":"Leonarda","family":"Serdani\u2010Neuhaus","sequence":"additional","affiliation":[{"name":"Evidence Generation &amp; Value Demonstration Takeda Pharma Vertrieb GmbH &amp; Co. KG Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"S\u00fcnwoldt","sequence":"additional","affiliation":[{"name":"Medical Affairs GI Takeda Pharma Vertrieb GmbH &amp; Co. KG Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"D\u00fcnweber","sequence":"additional","affiliation":[{"name":"Nordic medical affairs, Takeda Pharma A\/S, Vallensb\u00e6k Strand  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-6991","authenticated-orcid":false,"given":"Bernd","family":"Bokemeyer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Crohn Colitis Centre Minden Minden Germany"},{"name":"Clinic of General Internal Medicine I University Hospital Schleswig\u2010Holstein Campus Kiel 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