{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:56:25Z","timestamp":1792090585353,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is the leading chronic liver disease in children. Treatment with glucagon\u2010like\u2010peptide\u20101 receptor agonists (GLP\u20101RAs) have shown resolution of steatohepatitis with improvement in fibrosis in adults, yet pediatric studies are extremely limited. This study evaluates the impact of GLP\u20101RAs on pediatric MASLD, using alanine aminotransferase (ALT) reduction as a marker of improved disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective study in patients \u226418 years old with a diagnosis of MASLD, who were prescribed a GLP\u20101RA from January 2, 2018 and January 10, 2024 at the Children's Hospital of Philadelphia. Data were collected at baseline, 6 months, and at end\u2010of\u2010treatment (EOT). Inclusion required MASLD diagnosis per new criteria, elevated baseline ALT, and paired ALT values at baseline and EOT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two patients met inclusion criteria (mean age 15 years, 64% male, 55% White). ALT improved by a mean of 56\u2009U\/L at 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and by 37\u2009U\/L at EOT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Patients prescribed a GLP\u20101RA for type 2 diabetes mellitus (T2DM) had greater reductions in ALT compared to those treated for obesity. Improvements were also observed in aspartate aminotransferase (AST), gamma\u2010glutamyl transpeptidase (GGT), glycated hemoglobin (HbA1C), and triglycerides. Body mass index (BMI) percentile and\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score showed no significant changes, but BMI stabilization was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the largest pediatric study on GLP\u20101RAs in MASLD to date. On a GLP\u20101RA, ALT significantly improved at 6 months and EOT, suggesting their role in improving disease activity. This should thus be considered as an adjunct to lifestyle modification in treating pediatric MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70242","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:04:35Z","timestamp":1761624275000},"page":"146-155","source":"Crossref","is-referenced-by-count":8,"title":["Glucagon\u2010like peptide\u20101 receptor agonists in pediatric metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-9974","authenticated-orcid":false,"given":"Andrea M.","family":"Tou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Panganiban","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330110"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.05.028"},{"key":"e_1_2_9_5_1","volume-title":"Prevalence of Overweight, Obesity, and Severe Obesity Among Children and Adolescents Aged 2\u201319 Years: United States, 1963\u20131965 Through 2017\u20132018","author":"Fryar C","year":"2021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.1027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.047"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004202"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001482"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.11.039"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.0332"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001440"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2025.100164"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001368"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-024-01337-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S419245"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18331"},{"key":"e_1_2_9_20_1","unstructured":"FDA.FDA Approves Treatment for Serious Liver Disease Known as \u2018MASH.\u2019U.S. Food and Drug Administration; 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