{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:59:22Z","timestamp":1789545562642,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chronic nonbacterial osteomyelitis (CNO) is a rare, sterile autoinflammatory bone disorder that can develop in patients with inflammatory bowel disease (IBD). We aimed to identify the clinical features and natural history of patients with a dual diagnosis of CNO and IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of patients with a dual diagnosis of IBD and CNO were reviewed in centers from the Paediatric IBD Porto Group and IBD Interest Group of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Collected data included demographic characteristics, disease features, laboratory studies, bone imaging findings, and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010five patients (24 [53%] males), were included. Median age at the time of dual diagnosis was 10 (interquartile range [IQR]: 12\u201313) years. Thiry\u2010two (71%) patients were diagnosed with Crohn's disease, and 14 (44%) of them exhibited perianal disease. CNO presented in 15 patients (33%) within 3 months of IBD diagnosis, and in additional 20 (44%) patients after IBD diagnosis. In most patients, CNO manifested while IBD was clinically active, but not necessarily. However, in 10 (22%) patients CNO preceded the diagnosis of IBD with a median time 46 (25\u2013248) weeks. Upon diagnosis of CNO, most patients were treated with anti\u2010tumor necrosis factor. CNO remission was achieved in all patients at some point during follow\u2010up; However, complications occurred in six patients and included vertebral collapse, bone fracture, and bone deformity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CNO can be associated with active or quiescent intestinal inflammation, manifesting before, during, or after the diagnosis of IBD. While CNO remission was achieved in all patients, some developed significant bone complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70243","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:04:14Z","timestamp":1763460254000},"page":"487-494","source":"Crossref","is-referenced-by-count":2,"title":["Chronic nonbacterial osteomyelitis associated with pediatric inflammatory bowel disease: A multicenter retrospective study from the Paediatric inflammatory bowel disease Porto Group of ESPGHAN"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-2691","authenticated-orcid":false,"given":"Manar","family":"Matar","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva and the Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dita","family":"Cebecauerova","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adult Rheumatology Motol University Hospital Motol Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaija\u2010Leena","family":"Kolho","sequence":"additional","affiliation":[{"name":"Children's Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Scarallo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit Meyer Children's Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seamus","family":"Hussey","sequence":"additional","affiliation":[{"name":"National Children's Research Centre Royal College of Surgeons of Ireland and University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Yerushalmy\u2010Feler","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Institute \u201cDana\u2010Dwek\u201d Children's Hospital and the Gray Faculty of Medical and Health Sciences Tel\u2010 Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Pujol\u2010Muncunill","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Hepatology and Nutrition Department Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Rolandsdotter","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, Sweden and Department of Gastroenterology, Sachs\u2019 Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Distante","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit, Umberto I Hospital Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Granot","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital, Tel\u2010Hashomer  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Olbj\u00f8rn","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Akershus University Hospital Nordbyhagen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia K.","family":"Zetterstr\u00f6m","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition, Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Velasco","family":"Rodr\u00edguez\u2010Belv\u00eds","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"de Laffolie","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology University Children's Hospital Giessen, University of Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Ledder","sequence":"additional","affiliation":[{"name":"Juliet Keiden Institute of Paediatric Gastroenterology, Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Van Biervliet","sequence":"additional","affiliation":[{"name":"Pediateic Gastroenterology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Manuel","family":"Navas\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Unit Hospital Regional Universitario de Malaga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Limbergen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Konidari","sequence":"additional","affiliation":[{"name":"Aglaia Hyriakou Children's Hospital Athene Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"\u010copov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology and Nutrition. University Hospital Motol and 2nd Faculty of Medicine Motol Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror S.","family":"Shouval","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva and the Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02205.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-017-0405-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0495-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2013.824670"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.05.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa303"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523081335"},{"key":"e_1_2_7_9_1","article-title":"Eular\/American College of Rheumatology classification criteria for pediatric chronic nonbacterial osteomyelitis","author":"Zhao Y","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.115887"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-025-07306-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.09.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01215.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.959575"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.026"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003225"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-eular.3104"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10030502"},{"issue":"1","key":"e_1_2_7_21_1","first-page":"57","article-title":"Sacroiliac joint involvement in children with inflammatory bowel diseases","volume":"9","author":"Gerenli N","year":"2022","journal-title":"North Clin Istanb"},{"issue":"8","key":"e_1_2_7_22_1","article-title":"Chronic recurrent multifocal osteomyelitis: a comprehensive literature review","volume":"15","author":"Hassan M","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PG9.0000000000000007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2019.06.005"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:50:30Z","timestamp":1776397830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jpn3.70243"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70243","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]}}}