{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:43:08Z","timestamp":1776400988851,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Multiorgan abdominal involvement is a hallmark of Cystic fibrosis (CF). The CFAbd\u2010Score\n                      <jats:sup>\u00a9<\/jats:sup>\n                      is the first CF\u2010specific gastrointestinal patient reported outcome\u2010measure (PROM) developed following FDA\u2010guidelines. The PROM has proved to sensitively differentiate people with CF (pwCF) from healthy controls (HC). Furthermore, higher Scores in pwCF are associated with pancreatic insufficiency and history of surgery. Recently, in two large cohorts of pwCF, the PROM revealed significant and clinically meaningful improvements in abdominal symptoms (AS) in pwCF treated with Elexacaftor\u2010Tezacaftor\u2010Ivacaftor (ETI). In the present publication, we aim to validate the translated, linguistically and cross\u2010culturally adapted French version of the CFAbd\u2010Score\n                      <jats:sup>\u00a9<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Validation was performed following two forward translations and a review process by a German professional medical translator. The reviewed consensus version was psychometrically evaluated for validity and reliability in French\u2010speaking pwCF and HC cohorts, as well as in pwCF with and without ETI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 64 French\u2010speaking pwCF (mean age: 12.5 years) and 58 HC were included. Median CFAbd\u2010Score\n                      <jats:sup>\u00a9<\/jats:sup>\n                      in pwCF without ETI was significantly higher than in HC (18.2 vs\n                      <jats:italic>.<\/jats:italic>\n                      8.7 points\/\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), while Scores from ETI\u2010treated pwCF were almost as low as the HC\u2010range in many domains. Scores from ETI\u2010treated and nontreated pwCF differed significantly (8.4 vs\n                      <jats:italic>.<\/jats:italic>\n                      18.2 points\/\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The French version of the CFAbd\u2010Score has proved to be reliable and sensitive to capture AS in French\u2010speaking pwCF and to distinguish pwCF from HC. Furthermore, consistent with previous findings, the PROM sensitively detects ETI\u2010related differences in AS of pwCF with and without ETI therapy, and thus can be used in research and clinical routine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70244","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:19:11Z","timestamp":1762201151000},"page":"24-32","source":"Crossref","is-referenced-by-count":1,"title":["The validated French CFAbd\u2010Score reveals a lower burden of gastrointestinal symptoms in patients on Elexacaftor\/Tezacaftor\/Ivacaftor"],"prefix":"10.1002","volume":"82","author":[{"given":"Isabelle","family":"Sermet\u2010Gaudelus","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris Paris France"},{"name":"INSERM U1151, Institut Necker Enfants Malades Paris France"},{"name":"Centre de R\u00e9f\u00e9rence Maladie Rare\u2010Mucoviscidose H\u00f4pital Necker Enfants Malades Paris France"},{"name":"European Reference Network\u2010Lung Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Sadrieh","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sophie","family":"Bonnel","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladie Rare\u2010Mucoviscidose H\u00f4pital Necker Enfants Malades Paris France"},{"name":"H\u00f4pital Andr\u00e9 Mignot Le Chesnay France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Enaud","sequence":"additional","affiliation":[{"name":"Centre de Recherche Cardio\u2010Thoracique de Bordeaux Univ. Bordeaux Bordeaux France"},{"name":"CRCM P\u00e9diatrique Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Wizla","sequence":"additional","affiliation":[{"name":"CRCM P\u00e9diatrique H\u00f4pital Jeanne de Flandre Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Languepin","sequence":"additional","affiliation":[{"name":"CRCM P\u00e9diatrique Centre Hospitalier Universitaire Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambre","family":"Nangui","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladie Rare\u2010Mucoviscidose H\u00f4pital Necker Enfants Malades Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Deelawon","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladie Rare\u2010Mucoviscidose H\u00f4pital Necker Enfants Malades Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Rave","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Dabelow","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Barucha","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"},{"name":"Department of Gastroenterology Brandenburg Medical School (Theodor Fontane) Brandenburg an der Havel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-3750","authenticated-orcid":false,"given":"Carlos","family":"Zagoya","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Duckstein","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-7759","authenticated-orcid":false,"given":"Jochen Georg","family":"Mainz","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg Brandenburg an der Havel Germany"},{"name":"Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus\u2010Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00538-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061650"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3546-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30337-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2023-220100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-019-0159-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2023.2228194"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-019-00361-2"},{"key":"e_1_2_8_10_1","volume-title":"Registre fran\u00e7ais de la mucoviscidose \u2013 Bilan des donn\u00e9es 2022","author":"Mucoviscidose Vl","year":"2023"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0163278705275342"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.04054.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00292.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9606-8"},{"key":"e_1_2_8_15_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER) Center for Devices and Radiological Health (CDRH).Guidance for Industry: Patient\u2010Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims 2009;2019."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30113-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.877118"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.10.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.08.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124080"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17302-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.01.010"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.10.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914912117"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2004.07.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00026-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174463"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003357"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225004"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16143"},{"issue":"24","key":"e_1_2_8_31_1","first-page":"00092","article-title":"Cross\u2010cultural adaptation and validation of the CFAbd\u2010Score for gastrointestinal symptoms in patients with cystic fibrosis","volume":"0021","author":"Infantes FNS","year":"2024","journal-title":"J Pediatr"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1167407"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2024.07.004"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:51:15Z","timestamp":1776397875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jpn3.70244"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70244","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}