{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:36:04Z","timestamp":1787243764328,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Budesonide is a glucocorticoid with strong topical anti\u2010inflammatory properties and minimal systemic effects due to extensive first\u2010pass hepatic metabolism. It is designed for targeted delivery within the gastrointestinal (GI) tract and is available in oral and rectal formulations. Budesonide is indicated for various GI disorders, including Crohn's disease (CD, ulcerative colitis (UC) and eosinophilic oesophagitis (EoE), with specific formulations approved for different disease locations and severities. This narrative review evaluates the pharmacological profile, clinical applications and guideline recommendations surrounding the use of budesonide in both paediatric and adult GI disorders. Evidence from randomised controlled trials and real\u2010world studies supports the efficacy of budesonide in inducing remission in mild to moderate ileocaecal CD. It is recommended by ESPGHAN\/ECCO [European Society for Pediatric Gastroenterology, Hepatology, and Nutrition\/European Crohn's and Colitis Organisation] guidelines as a therapeutic alternative in selected paediatric patients when exclusive enteral nutrition is not feasible. In UC, budesonide\u2010multimatrix tablets and rectal foam formulations may be effective for distal and left\u2010sided disease, though they are generally less effective than systemic corticosteroids or 5\u2010aminosalicylic acid and are reserved for patients with contraindications to standard therapies. In EoE, topical swallowed budesonide has shown promising results in inducing clinical and histological remission, with increasing data supporting its use in children. Although budesonide is associated with fewer systemic adverse effects, long\u2010term use may still pose risks such as growth suppression and hypothalamic\u2010pituitary adrenal axis suppression, necessitating careful monitoring. Budesonide offers a valuable treatment option when used in alignment with disease phenotype, formulation properties and patient\u2010specific considerations.<\/jats:p>","DOI":"10.1002\/jpn3.70245","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:03:38Z","timestamp":1761624218000},"page":"60-69","source":"Crossref","is-referenced-by-count":2,"title":["Drugs in focus: Budesonide and its role in paediatric gastrointestinal disorders"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-4977","authenticated-orcid":false,"given":"Sohail","family":"Aziz","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Campania \u201cLuigi Vanvitelli\u201d Napels Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Puoti","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Hepatology Santobono\u2010Pausilipon Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Assa","sequence":"additional","affiliation":[{"name":"The Pediatric Gastroenterology Unit, Kaplan Medical Center Rehovot and the Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zrinjka","family":"Misak","sequence":"additional","affiliation":[{"name":"Referral Centre for Paediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Medical School University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mas","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie, H\u00e9patologie, Nutrition et Maladies H\u00e9r\u00e9ditaires du M\u00e9tabolisme, H\u00f4pital des Enfants, and IRSD Universit\u00e9 de Toulouse, INSERM, INRAE, ENVT, UPS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology &amp; Motility Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"Dolin\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Centre Maribor, and Department of Pediatrics, Medical Faculty University of Maribor Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Martin\u2010de\u2010Carpi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Scheers","sequence":"additional","affiliation":[{"name":"Pediatric 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