{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:29:21Z","timestamp":1791955761022,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Approximately 9% of children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) have pancreatogenic diabetes during childhood; lifetime risk approaches 50%. To date, data are limited on pathophysiology and biomarkers identifying those at highest risk. This pilot study investigated glycemic physiology in children with ARP or CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children (5\u201321 years) with an established diagnosis of CP or ARP, and participants of INSPPIRE\u20102 (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) were enrolled. Mixed meal tolerance testing (MMTT) measured glucose, insulin, C\u2010peptide, glucagon, glucagon\u2010like peptide\u20101 (GLP\u20101) and pancreatic polypeptide (PP) at \u22125, \u22121, 0, 30, 60, 90, 120\u2009min before\/after a Boost HP beverage. Other measures included hemoglobin A1c, continuous glucose monitoring (CGM, Dexcom Pro), HLA haplotype, and diabetes autoantibodies. Glycemic variability metrics were calculated using \u201ccgmanalysis.\u201d Dysglycemia was defined by fasting glucose \u2265100\u2009mg\/dL or HbA1c\u2009\u2265\u20095.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty participants were enrolled (mean age 16.3 years; 65% female, 60% non\u2010Hispanic white, 2 with pre\u2010existing diabetes). Mean HbA1c was 5.7% (range 5.0\u20138.9); 7\/20 had dysglycemia, 1 with previously unrecognized diabetes. Those with dysglycemia differed from normoglycemic participants by having greater insulin resistance, lower GLP\u20101, and trend toward lower insulin and C\u2010peptide but higher PP on MMTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this small study, 35% of children with pancreatitis had dysglycemia, which may be mechanistically related to insulin resistance. Other trends associated with dysglycemia included impaired insulin secretion, reduced GLP\u20101, and unexpectedly elevated PP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70263","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:02:38Z","timestamp":1763460158000},"page":"549-556","source":"Crossref","is-referenced-by-count":2,"title":["Early mechanisms of diabetes development in pediatric pancreatitis: A pilot study"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-4858","authenticated-orcid":false,"given":"Maria Graciela","family":"Parra Villasmil","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Stead Family Children\u2032s Hospital University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melena","family":"Bellin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherina","family":"Pinnaro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stead Family Children\u2032s Hospital University of Iowa Iowa City Iowa USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fati","family":"Craighead","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Cress","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stead Family Children\u2032s Hospital University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Uc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stead Family Children\u2032s Hospital University of Iowa Iowa City Iowa USA"},{"name":"Department of Radiation Oncology University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lowe","sequence":"additional","affiliation":[{"name":"Washington University in St Louis St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Health Data Science University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie Larson","family":"Ode","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stead Family Children\u2032s Hospital University of Iowa Iowa City Iowa USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center Minneapolis Minnesota 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