{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:52:19Z","timestamp":1790113939632,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extraintestinal manifestations (EIMs) manifest in 6%\u201047% of patients with inflammatory bowel disease (IBD). Here, we characterize the course of EIMs in pediatric patients receiving vedolizumab included in the VedoKids cohort study. This was a subgroup analysis of the pediatric VedoKids cohort, a multicenter, prospective study of children (aged 0\u201318 years) with IBD treated with vedolizumab and followed through 54 weeks. EIMs were identified in 18\/142 (12.6%) children at baseline; 56% of these cases were articular EIMs; the EIMs resolved in 89% within 18 months. Concomitant medications were administered in 72% of EIM cases, most of which were ongoing at the time of vedolizumab initiation. Of the 124 children without EIMs, five (4%) developed EIMs during follow up: three arthritis, two cutaneous manifestations. The presence of EIMs did not affect the durability of vedolizumab treatment. In conclusion, most EIMs in children with IBD resolved with vedolizumab treatment, but almost half received concomitant medications.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    Identifier: NCT02862132.\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT02862132?term=NCT02862132%26rank=1\">https:\/\/clinicaltrials.gov\/study\/NCT02862132?term=NCT02862132&amp;rank=1<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/jpn3.70276","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:00:42Z","timestamp":1763460042000},"page":"495-502","source":"Crossref","is-referenced-by-count":2,"title":["Vedolizumab for extraintestinal manifestations in pediatric inflammatory bowel disease: Results from the VedoKids study"],"prefix":"10.1002","volume":"82","author":[{"given":"Giulia","family":"D'Arcangelo","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Turner","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Ledder","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Orlanski\u2010Meyer","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Broide","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases Shamir Medical Center Be'er Ya'akov Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Granot","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Edmond and Lily Safra Children's Hospital, Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Matar","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University Tel Aviv Israel"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition Schneider Children's Medical Center of Israel Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seamus","family":"Hussey","sequence":"additional","affiliation":[{"name":"National Centre for Paediatric Gastroenterology Children's Health Dublin Ireland"},{"name":"Department of Paediatrics University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Yerushalmy\u2010Feler","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University Tel Aviv Israel"},{"name":"Pediatric Gastroenterology Institute, \u201cDana\u2010Dwek\u201d Children's Hospital Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Norden","sequence":"additional","affiliation":[{"name":"Department for Children and Young People Hvidovre University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmo","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-4004","authenticated-orcid":false,"given":"Marina","family":"Aloi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico di Milano Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0490-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i10.2300"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz095"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad075"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00307-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad108"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31560"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000480260.28955.65"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14419"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy065"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.933357"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy125"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:51:33Z","timestamp":1776397893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jpn3.70276"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70276","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]}}}