{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:43:29Z","timestamp":1776401009682,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether low\u2010volume transanal irrigation (L\u2010TAI) is effective as add\u2010on to oral laxative therapy for children with functional constipation and retentive fecal incontinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two\u2010arm randomized controlled trial, including children aged 4\u201314 suffering from retentive fecal incontinence. All included children were refractory to at least 2 months treatment with stool softening oral laxatives. Children were included across three pediatric departments in Denmark and randomized into two treatment groups. Treatment duration was 6 weeks. The control group continued oral laxative therapy. The intervention group received L\u2010TAI as add\u2010on. The primary objective was evaluating reduction in fecal incontinence episodes. Secondary objectives included assessment of constipation symptoms, rectal diameter, and well\u2010being based on the WHO\u20105 questionnaire. Participants were classified as nonresponders (0%\u201349% reduction) or responders (partial response\u2009=\u200950%\u201399% reduction, or full response\u2009=\u2009100% reduction).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty children were included. The respective median ages were 7 (interquartile range [IQR]\u2009=\u20093) in the intervention group and 6 years (IQR\u2009=\u20091) in the control group. In the intervention group, 75% were responders with 35% experiencing full response, while 33% in the control group were responders, with 4.8% experiencing full response (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020 for response and full response respectively). At follow\u2010up, 55% of the intervention group and 90.5% of the control group still met ROME\u2010IV criteria for constipation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>L\u2010TAI is effective as add\u2010on to oral laxatives in treating fecal incontinence and constipation. Further studies with longer follow\u2010up periods are needed to assess long\u2010term effects.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial identification number:<\/jats:bold>\n                      NCT05570318 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05570318\">https:\/\/clinicaltrials.gov\/study\/NCT05570318<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70279","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:54:19Z","timestamp":1763459659000},"page":"425-433","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of low volume transanal irrigation in children with retentive fecal incontinence: A randomized controlled trial"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4837-7212","authenticated-orcid":false,"given":"Signe \u00d8bo","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Axelgaard","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iben M\u00f8ller","family":"J\u00f8nsson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolette","family":"Brodersen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Bang","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte Ryom","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Hagstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise","family":"Borch","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO | Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.029"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.16.3.213"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000266"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1515-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12103"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003056"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.098335"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.12.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903583855"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181afcdc3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2902-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003515"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001236"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/954315"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-015-3735-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001483"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22751"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000376585"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000142686.09532.46"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.055"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-025-04813-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3310\/pgfar09140"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2013.22.10.575"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3868"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3639"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-024-06083-4"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12158"}],"container-title":["Journal 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