{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:42:34Z","timestamp":1776400954350,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this follow\u2010up was to investigate how reduced iron concentration and added bovine lactoferrin in infant formula affect neurodevelopment, iron status, and growth at 12 months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Swedish healthy term formula\u2010fed infants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009180) were randomly assigned to receive, from 6 weeks to 6 months of age, a low\u2010iron formula (2\u2009mg\/L) fortified with bovine lactoferrin (1.0\u2009g\/L) (Lf+,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972), the same formula without lactoferrin fortification (Lf\u2212,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972) or a control standard formula with 8\u2009mg\/L and no lactoferrin (CF,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936). Breast\u2010fed infants were recruited as a reference (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972). At 12 months of age, Bayley Scales of Infant and Toddler Development\u2010III (BSID\u2010III), iron status, and anthropometrics were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no intervention effects on BSID\u2010III. Explored outcomes were unaffected by lactoferrin and the two low\u2010iron groups (Lf+ and Lf\u2212) were combined. The low\u2010iron group had lower hepcidin (37.8 vs. 49.4\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), compared to the CF group. Furthermore, they had iron status indicators more similar to the breast\u2010fed reference group. The prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) was low with no significant differences among groups. Weight and length were unaffected by intervention, however head circumference was minimally higher in infants fed low\u2010iron formula compared to CF with mean difference (95% confidence interval) of 0.3 (0.0\u20130.6) standard\u2010deviation\u2010scores,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Infant formula iron concentration at 2\u2009mg\/L was adequate in this population of infants with low risk of ID. Adding bovine lactoferrin did not affect the explored long\u2010term clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70301","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:40:15Z","timestamp":1764236415000},"page":"574-583","source":"Crossref","is-referenced-by-count":1,"title":["Infant formula iron fortification of 2 vs. 8\u2009mg\/L does not increase the risk of iron deficiency or impact neurodevelopment at 12 months"],"prefix":"10.1002","volume":"82","author":[{"given":"Maria","family":"Bj\u00f6rmsj\u00f6","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Hernell","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics Ume\u00e5 University Ume\u00e5 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