{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:43:15Z","timestamp":1776400995105,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Data on the relationship between body composition and strength in children with intestinal failure (IF) is lacking. The objectives were to (1) assess strength in children with IF compared to published norms; (2) examine the relationship between body composition and strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children aged 4\u201318 years with IF, excluding those with significant developmental delay or mobility challenges, were included. Functional strength was assessed using the Bruininks\u2013Oseretsky Test of Motor Proficiency\u20102 (BOT\u20102) and muscle strength was measured with a dynamometer for handgrip strength (HGS) and knee flexion\/extension. Body composition was assessed using dual\u2010energy X\u2010ray absorptiometry. Two\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test compared strength in IF patients to published norms, and the relationship between body composition and strength was analyzed using linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010one children (71% male, mean age 9.9 years) were included. Twelve (39%) received parenteral nutrition (PN). Children with IF had significantly lower HGS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), knee flexion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and extension (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to published norms. Specifically, 80.6% scored below the mean for HGS, 71.0% for knee flexion, and 74.2% for extension. BOT\u20102 revealed 26.9% had scores less than \u22121 SD. No significant differences in strength were found between those on enteral nutrition or PN. A significant positive relationship between functional strength and increased fat\u2010free mass, and decreased fat mass was found (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), with male sex strengthening the relationship (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children with IF, both on enteral nutrition and PN, are weaker than healthy literature controls. Decreased strength was associated with lower fat\u2010free mass. This relationship was stronger in males than in females, highlighting the need to further investigate the mechanisms behind body composition and strength in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT04610918.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70307","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T10:46:27Z","timestamp":1765277187000},"page":"615-624","source":"Crossref","is-referenced-by-count":0,"title":["Reduced strength is associated with abnormal body composition in children with a history of intestinal failure"],"prefix":"10.1002","volume":"82","author":[{"given":"Dianna","family":"Yanchis","sequence":"first","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"So","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Physical Therapy University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Patterson","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Physical Therapy University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Belza","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Garofalo","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Wong\u2010Sterling","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Silva","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Avitzur","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Wales","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie M.","family":"Hulst","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto Toronto Ontario Canada"},{"name":"Department of Nutritional Sciences University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6835-1366","authenticated-orcid":false,"given":"Glenda","family":"Courtney\u2010Martin","sequence":"additional","affiliation":[{"name":"Research Institute, The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Nutritional Sciences University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000493"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000484"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060664"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.03.018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2055"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002873"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.02.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1527"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303516"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.057935"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2265"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.09.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003884"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3181b2297b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4236\/health.2012.41001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2021.09.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.04.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001722"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2232"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.031"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000521396.85360.82"},{"issue":"450","key":"e_1_2_7_23_1","first-page":"76","article-title":"WHO child growth standards based on length\/height, weight and age","volume":"95","author":"De Onis M","year":"2006","journal-title":"Acta Paediatr Int J Paediatr"},{"key":"e_1_2_7_24_1","volume-title":"Test of Motor Proficiency","author":"Brett D","year":"2005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2018.11.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/J006v27n04_06"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hansur.2022.02.007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0000000000000366"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0b013e318227ccff"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1557988314549749"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13784"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2004.12.003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12853"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab260"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002107"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003553"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30746"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae190.1033"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:51:05Z","timestamp":1776397865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jpn3.70307"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70307","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}