{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:25:47Z","timestamp":1788690347210,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Deficiency of serum 25\u2010hydroxyvitamin D [25(OH)D] was associated with decreased short\u2010term response to anti\u2010tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) agents in adults with inflammatory bowel disease (IBD). The aim of this study was to evaluate the association between serum 25(OH)D levels and the outcome of children with IBD undergoing anti\u2010TNF\u2010\u03b1 therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with IBD who were treated with anti\u2010TNF\u2010\u03b1 agents and whose 25(OH)D levels had been measured at the initiation of therapy were included. Demographic, clinical, and laboratory data were collected retrospectively between 1\/2012 and 1\/2022. 25(OH)D levels above 30\u2009ng\/mL were considered sufficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 150 children with IBD were treated with anti\u2010TNF\u2010\u03b1 agents, and 84 of them (58 Crohn's disease, 26 ulcerative colitis, median [interquartile range] age 15.2 [12.8\u201316.5] years) met the inclusion criteria. Sixty\u2010five (77%) patients were 25(OH)D\u2010deficient. Adequate 25(OH)D levels were associated with clinical response (hazard ratio [HR]\u2009=\u20094, 95% confidence interval [CI] 1.43\u201311.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), and clinical remission (HR\u2009=\u20094.62, 95% CI 2.56\u20138.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). While anti\u2010TNF\u2010\u03b1 trough levels were comparable between 25(OH)\n                      <jats:sc>d<\/jats:sc>\n                      \u2010deficient and non\u2010deficient children, intensification of anti\u2010TNF\u2010\u03b1 therapy was more prevalent among children with 25(OH)D deficiency (65% vs. 21%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adequate serum 25(OH)D is an independent predictor of a favorable outcome of pediatric IBD under anti\u2010TNF\u2010\u03b1 therapy.<\/jats:p>\n                  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affiliated to the Gray Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan","family":"Damari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Assuta Ashdod University Medical Center, Ashdod, Israel, and the Faculty of Health Sciences, Ben\u2010Gurion University of the Negev Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Cohen","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Institute, \u201cDana\u2010Dwek\u201d Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Gray Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Yerushalmy\u2010Feler","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Institute, \u201cDana\u2010Dwek\u201d Children's 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