{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:52:25Z","timestamp":1791615145261,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rotavirus vaccine clinical trials and post\u2010licensure evaluations found malnourished children may have lower protection against rotavirus diarrhea hospitalizations than well\u2010nourished children. On a population level, rotavirus vaccines are less protective in high child mortality settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed rotavirus vaccine effectiveness (VE) among malnourished and well\u2010nourished children categorized using four anthropometric malnutrition indicators, birthweight, and reported malnutrition from medium to high child mortality countries in the Multi\u2010National Subpopulations Study to Evaluate Rotavirus Vaccines (MNSSTER\u2010V) dataset. We calculated child\u2010level z\u2010scores for weight\u2010for\u2010age, length\u2010for\u2010age, weight\u2010for\u2010length, and mid\u2010upper arm circumference (MUAC), and the site\u2010level proportion implausible z\u2010scores. Sites with published VE estimates by nutritional status or those with &lt;3% implausible values were included in the final analysis. Z\u2010scores &lt;\u22122 were considered moderate\u2010to\u2010severe malnutrition and &lt;\u22123 were considered severe malnutrition. We calculated complete series rotavirus VE in each malnourished and well\u2010nourished group using an unconditional adjusted logistic regression model, where VE\u2009=\u2009(1\u2009\u2212\u2009odds ratio of vaccination among cases and controls)\u2009\u00d7\u2009100, where cases and controls were children who tested rotavirus positive and negative, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete series VE was more protective among children without stunting (normal length\u2010for\u2010age) (59%; 95% confidence interval [CI]: 49\u201367) compared to children with moderate\u2010to\u2010severe stunting (42%; 95% CI: 19\u201358) and severe stunting (31%; 95%CI: \u221214 to 58). Adjusted VE point estimates were similar among malnourished and well\u2010nourished children using the other anthropometric and birthweight indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings clearly show that chronic malnutrition negatively impacted rotavirus VE. Efforts to address and prevent malnutrition generally may further reduce the burden of rotavirus morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70322","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:51:01Z","timestamp":1767588661000},"page":"790-800","source":"Crossref","is-referenced-by-count":4,"title":["Oral rotavirus vaccine effectiveness among malnourished children in 19 countries: Findings from the MNSSTER\u2010V project"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-6156","authenticated-orcid":false,"given":"Eleanor","family":"Burnett","sequence":"first","affiliation":[{"name":"Viral Gastroenteritis Branch, Division of Viral Diseases National Center for Immunization and Respiratory Diseases Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Ticklay","sequence":"additional","affiliation":[{"name":"Child 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Lalaina","family":"Robinson","sequence":"additional","affiliation":[{"name":"CHU M\u00e8re Enfant Tsaralal\u00e0na Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Omore","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI) Centre for Global Health Research (CGHR) Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najibullah","family":"Safi","sequence":"additional","affiliation":[{"name":"JS Consultancy Kabul Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Van","family":"Trang","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet","family":"Kisakye","sequence":"additional","affiliation":[{"name":"Uganda Country Office World Health Organization Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine","family":"Uwimana","sequence":"additional","affiliation":[{"name":"Department of Pathology Kigali University Teaching Hospital, Institute of Applied Sciences Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kofi","family":"N'Zue","sequence":"additional","affiliation":[{"name":"Cote d'Ivoire Country Office World Health Organization Abidjan Cote d'Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Groome","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences University of the Witwatersrand Johannesburg South 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Luhata","family":"Lungayo","sequence":"additional","affiliation":[{"name":"Programme \u00e9largi de vaccination Minist\u00e8re de la Sant\u00e9 Kinshasa Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausta","family":"Michael","sequence":"additional","affiliation":[{"name":"Ministry of Health Dar es Salaam Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayane","family":"Sahakyan","sequence":"additional","affiliation":[{"name":"National Institute of Health, Ministry of Health the Republic of Armenia Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Rey\u2010Benito","sequence":"additional","affiliation":[{"name":"Pan American Health Organization (PAHO) Washington DC District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goitom","family":"Weldegebriel","sequence":"additional","affiliation":[{"name":"WHO\/AFRO Inter Country 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