{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:42:53Z","timestamp":1776400973001,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Enteral nutrition interruptions (ENIs) are common in critically ill children and may cause underfeeding. Volume\u2010based feeding practices (VBFPs) mitigate ENIs, but their use has not been reported in pediatric critical care. We analyzed whether a modified VBFP (MVBFP), based on compensatory feeding over the subsequent 24\u2009h, is feasible and safe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective longitudinal study of critically ill children aged 1 month\u201318 years receiving enteral nutrition in whom an MVBFP was applied. Compensatory increased enteral feeding goal rates (CIEFGR) were defined as instances in which the volume lost due to an ENI was replaced gradually over the subsequent 24\u2009h by increasing the infusion rate. Data included demographics, ENI characteristics, volume and rate during compensatory feeding, caloric and protein intake, and gastrointestinal or metabolic adverse effects. We also recorded pre\u2010existing gastrointestinal conditions and formula type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010eight CIEFGR were recorded in 21 children. The median compensatory period was 24\u2009h (interquartile range [IQR]: 17.5\u201324), with a median additional volume of 20\u2009mL\/kg (IQR: 10.5\u201333.1), corresponding to increases of 18.8\u2009kcal\/kg (IQR: 9.8\u201327.8) and 0.5\u2009g\/kg protein (IQR: 0.23\u20130.8). The infusion rate rose from 21 to 27\u2009mL\/h (IQR: 20\u201333). Gastrointestinal signs (increased gastric residual volume, abdominal distension, nausea) occurred in 10.7% of episodes, were mild, and required no intervention. No significant metabolic alterations were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An MVBFP using compensatory feeding in critically ill children appears feasible and safe, improving caloric and protein delivery without increasing gastrointestinal side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70335","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:30:51Z","timestamp":1767684651000},"page":"812-818","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and safety of a modified volume\u2010based feeding protocol in critically ill children: A pilot study"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-2528","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Solana Garc\u00eda","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Department of Public and Maternal\u2010Child Health Universidad Complutense Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Mother and Child Health and Development Network (REDSAMID) ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16\/0022) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"L\u00f3pez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Mother and Child Health and Development Network (REDSAMID) ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16\/0022) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Manrique Mart\u00edn","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Mother and Child Health and Development Network (REDSAMID) ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16\/0022) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"L\u00f3pez\u2010Herce Cid","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Department of Public and Maternal\u2010Child Health Universidad Complutense Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Mother and Child Health and Development Network (REDSAMID) ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16\/0022) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05922-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003337"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000222115.91783.71"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15040855"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111580"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002382"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1751143719847321"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8991"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114540004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04439-0"},{"issue":"3","key":"e_1_2_7_12_1","first-page":"392","article-title":"Efficacy of volume\u2010based feeding (VBF) protocol on critically ill patients: a meta\u2010analysis and systematic review","volume":"30","author":"Wang L","year":"2021","journal-title":"Asia Pac J Clin 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admitted to intensive care unit","volume":"36","author":"Faramarzi E","year":"2020","journal-title":"Pak J Med Sci"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta24230"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1856-y"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2018.11.005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2021.12.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081775"},{"issue":"4","key":"e_1_2_7_28_1","first-page":"743","article-title":"Validation of the nutritrauma concept for the detection of potential harmful effects of medical nutritional treatment in critically ill patients in real life","volume":"41","author":"Parisi J","year":"2024","journal-title":"Nutr 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