{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:49:04Z","timestamp":1775450944975,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>STRIDE (selecting therapeutic targets in inflammatory bowel disease) established evidence\u2010based targets for treat\u2010to\u2010target strategies in inflammatory bowel disease (IBD). STRIDE\u2010II designates clinical remission, C\u2010reactive protein (CRP) normalization, and fecal calprotectin (FC) reduction as short\u2010 to intermediate\u2010term targets, and mucosal healing as a long\u2010term target. This study evaluated STRIDE\u2010II application and disease control in a real\u2010world pediatric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed newly diagnosed pediatric IBD patients (ages 3\u201318 years) treated according to guidelines between June 2017 and January 2023. Time\u2010to\u2010reach STRIDE\u2010II targets and time\u2010to\u2010first flare were assessed over 52 weeks using disease activity indices, inflammatory biomarkers (CRP, FC), and endoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010four patients were included (37 Crohn's disease [CD], 37 ulcerative colitis [UC]). All CD patients received primary maintenance therapy with immunomodulators or biologics, versus 51% UC patients. Clinical remission and CRP normalization occurred within 5\u201310 weeks; FC normalization within 12\u201319 weeks. By 6 months, combined targets (clinical remission plus CRP and FC normalization) were achieved by 54% of CD patients and 43% of UC patients. Clinical relapse after remission occurred more frequently in UC than in CD (67% vs. 43%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0334). Follow\u2010up endoscopy at a median of 41 weeks (CD) and 52 weeks (UC) showed endoscopic healing in 7\/18 (39%) CD and 13\/22 (59%) UC patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most pediatric IBD patients achieved clinical remission and CRP normalization within STRIDE\u2010II timeframes, whereas FC normalization occurred later, and relapses\u2014particularly in UC\u2014remained common. The notable proportion of patients with suboptimal disease control underscores the need for continuous monitoring in pediatric IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70345","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:07:59Z","timestamp":1768802879000},"page":"1006-1018","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world data on STRIDE\u2010II treatment targets in a pediatric cohort with inflammatory bowel disease"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0594-1282","authenticated-orcid":false,"given":"Marie\u2010Luise","family":"Frank","sequence":"first","affiliation":[{"name":"Department of Pediatrics Dr. von Hauner Children's Hospital, University Hospital Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-9551","authenticated-orcid":false,"given":"Thu Giang 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