{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:08:12Z","timestamp":1784675292512,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study evaluated enothelial function in children with\n                      <jats:italic>Helicobacter pylori (H. pylori<\/jats:italic>\n                      ) using flow\u2010mediated dilatation (FMD) and assessed the effect of eradication therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty symptomatic children were enrolled consecutively and divided into two groups after endoscopy: 30 children with confirmed\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection, and 30 children with negative\n                      <jats:italic>H. pylori<\/jats:italic>\n                      . Thirty age\u2010 and sex\u2010matched healthy children served as controls. Complete blood count, high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), and complete lipid profiles were obtained. Endothelial function was assessed by brachial artery FMD.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      positive patients received triple therapy for 2 weeks and were reassessed after 3 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori\u2010<\/jats:italic>\n                      positive children had significantly higher hs\u2010CRP (6.7\u2009\u00b1\u20092.3), cholesterol (190.2\u2009\u00b1\u200931.2), triglycerides (133.2\u2009\u00b1\u200960.5), and low\u2010density lipoprotein (129.6\u2009\u00b1\u200924.7) than\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010negative (2.9\u2009\u00b1\u20091.6, 167.6\u2009\u00b1\u200941.0, 86.3\u2009\u00b1\u200923.6, and 95.5\u2009\u00b1\u200928.8) and controls (0.7\u2009\u00b1\u20090.2, 151.8\u2009\u00b1\u200931.3, 90.5\u2009\u00b1\u200932.5, and 84.5\u2009\u00b1\u200923.3) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Conversely, hemoglobin (9.7\u2009\u00b1\u20091.2), high\u2010density lipoprotein (HDL) (35.9\u2009\u00b1\u20099.1), and FMD (6.07\u2009\u00b1\u20091.60) were significantly lower compared to the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010negative (11.5\u2009\u00b1\u20090.8, 45.4\u2009\u00b1\u200913.3, and 9.500\u2009\u00b1\u20091.20) and controls (11.7\u2009\u00b1\u20090.9, 55.0\u2009\u00b1\u200910.1, and 9.80\u2009\u00b1\u20091.20) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After eradication, responders showed significant increases in hemoglobin, HDL, and FMD with significant decreases in hs\u2010CRP and other lipid profiles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). FMD correlated negatively with symptoms\u2032 duration, hs\u2010CRP, cholesterol, and Sydney score, but positively with HDL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Children with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection exhibited endothelial dysfunction and dyslipidemia, both of which improved significantly after successful eradication.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70351","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T11:22:32Z","timestamp":1770031352000},"page":"988-995","source":"Crossref","is-referenced-by-count":1,"title":["Vascular endothelial function in pediatric patients with\n                    <i>Helicobacter pylori<\/i>\n                    infection and its 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