{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:49:59Z","timestamp":1775450999453,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 GM152319"],"award-info":[{"award-number":["T32 GM152319"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>After hepatoportoenterostomy (HPE), a minority of biliary atresia (BA) patients reach adolescence without liver transplantation. Several serum markers have been suggested to better predict post\u2010HPE outcomes in BA patients. We aimed to identify serum predictors of native liver survival (NLS) in post\u2010HPE BA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, MEDLINE, SCOPUS, and EMBASE databases to identify publications from 1946 through December 2023. Studies included reported serum values as prognostic factors for BA after HPE, specifically total bilirubin (TB), alanine transaminase (ALT), gamma\u2010glutamyl transferase (GGT), matrix metalloproteinase 7 (MMP\u20107), and total bile acids (TBA). We defined nonfunctioning HPE as persistent jaundice, cirrhosis, LT, or death. We calculated pooled serum variables, including hazard and odds ratios, for NLS using inverse variance weighting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty studies were included in the meta\u2010analysis including a total of 4399 BA patients, 2073 and 1793 had successful versus nonfunctioning HPE, respectively. The mean HPE age for the successful group was significantly less (63.3 vs. 69.5 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). TB was significantly elevated in the nonfunctioning group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Pooled ALT and GGT were significantly lower in the successful group 1\u20133 months and &gt;5 years after HPE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The successful group had significantly lower serum TBA (27.55 vs. 69\u2009\u03bcmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001)\u2009&gt;\u20095 years after HPE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Established serum values ALT, GGT, and TB are useful for prognostic assessment post\u2010HPE. MMP\u20107 and TBA require additional evaluation to determine their prognostic relevance for NLS in BA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70355","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:37:28Z","timestamp":1769686648000},"page":"939-948","source":"Crossref","is-referenced-by-count":0,"title":["Serum predictors of native liver survival post\u2010Kasai: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-7364","authenticated-orcid":false,"given":"Ahmad","family":"Anouti","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Dahshi","sequence":"additional","affiliation":[{"name":"School of Medicine Case Western Reserve University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Cotter","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases University of Texas Southwestern Medical, Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tebyan A.","family":"Rabbani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, Nutrition Stanford University Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Corbitt","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-9425","authenticated-orcid":false,"given":"Sara","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Texas Southwestern, Children's Health Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.01.040"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103689"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.14-2-e63"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15689"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04925-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2022.25.5.353"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"The impact of serum total bilirubin, alanine transaminase and gamma\u2010glutamyl transferase on survival of biliary atresia patients following Kasai procedure","volume":"75","author":"Noor HZ","year":"2020","journal-title":"Med J Malaysia"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32800"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"S259","article-title":"The utility of non\u2010invasive hepatic ADC and age\u2010adjusted serum MMP\u20107 in the diagnosis of biliary atresia among cholestatic infants","volume":"17","author":"Wu JF","year":"2023","journal-title":"Hepatol Int"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-022-10322-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_13_1","unstructured":"Study Quality Assessment Tools.U.S. Department of Health and Human Services.https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools. 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