{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:02:59Z","timestamp":1785132179342,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The complex care needs of pediatric patients with short bowel syndrome\u2010associated intestinal failure (SBS\u2010IF) can negatively impact the health\u2010related quality of life (HRQoL) of patients and their caregivers. We assessed the impact of teduglutide on HRQoL of pediatric patients with SBS\u2010IF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two long\u2010term extension (LTE) studies (NCT02949362, NCT02954458) assessed HRQoL over 96 weeks using the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales and the PedsQL Family Impact Module. Patients included in this analysis received teduglutide in one of three randomized Phase 3 parent studies and the respective LTE study. We assessed changes in HRQoL over time, as well as the impact of attaining enteral autonomy on HRQoL and predictors of change in HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In pediatric patients with SBS\u2010IF receiving teduglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969), the total mean (standard deviation) patient\u2010reported PedsQL score was 75.0 (16.2). Higher mean number of stools per day at LTE study baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) predicted increased patient\u2010reported HRQoL. Longer teduglutide exposure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), increasing length of remnant small intestine (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), and older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) predicted higher caregiver\u2010proxy\u2010reported HRQoL. Mean PedsQL scores remained stable over 96 weeks regardless of patients achieving enteral autonomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HRQoL of pediatric patients with SBS\u2010IF treated with teduglutide was generally stable over 96 weeks. Predictors of improved HRQoL included higher baseline stool number, longer teduglutide treatment duration, greater length of small intestine, and older age. To better understand these observations, future studies should assess HRQoL before initiation of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>Clinical trials NCT02949362 and NCT02954458.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70358","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:56:09Z","timestamp":1773986169000},"page":"54-62","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life for pediatric patients with short bowel syndrome\u2010associated intestinal failure treated with teduglutide"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5140-2956","authenticated-orcid":false,"given":"Danielle","family":"Wendel","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Seattle Children's Hospital, University of Washington School of Medicine Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Wales","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kocoshis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Venick","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition UCLA Mattel Children's Hospital Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Carter","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles and Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cohran","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheney","family":"Matthews","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals, U.S.A., Inc. Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram P.","family":"Raphael","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals, U.S.A., Inc. Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Robinson","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals, U.S.A., Inc. 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