{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:49:55Z","timestamp":1775450995619,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identifying predictors of unfavorable disease course in pediatric ulcerative colitis (UC) will impact therapeutic strategy. We aimed to define predictors of nonremission 2 years after diagnosis in pediatric patients with UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis of prospectively collected data from ImproveCareNow included pediatric UC patients (&lt;18 years) diagnosed between 2007 and 2023 with at least a 2\u2010year follow\u2010up. Remission was defined as a pediatric UC activity index (PUCAI)\u2009&lt;\u200910 points. Statistical analysis was performed using the International Business Machines Corporation Statistical Package for the Social Sciences (SPSS) version 29. Demographic information at diagnosis\/enrollment (T0), first visit (T1) and follow\u2010up (T2, closest to 24 months) were calculated between relevant groups. Binary logistic regression was used to identify outcome predictors. Multiple imputation was used for missing data. This study was approved by the Ethics Committee (Protocol 23135\u2010ICN_UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 1290 pediatric UC patients. Two years after diagnosis, 390 patients (30%) were not in remission at T2. Differences in disease severity and treatment were observed at T1 and T2. PUCAI (mild odds ratio [OR]\u2009=\u20091.946, moderate OR\u2009=\u20091.735, or severe disease OR\u2009=\u20093.183,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), the use of immunomodulators (IM) (OR\u2009=\u20090.631,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.053) and body mass Index (BMI)\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score (OR\u2009=\u20091.149,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) at T1 (mean 30 days) predicted non\u2010remission at T2 with poor discriminating ability (area under the curve 0.599\u20130.621).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Predictors for unfavorable disease course were increasing disease severity according to PUCAI (vs\n                      <jats:italic>.<\/jats:italic>\n                      inactive disease), increasing BMI\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score (per\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score increase) and nonuse of IM at T1. These predictors may impact therapeutic strategy shortly after diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70370","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:24:21Z","timestamp":1770269061000},"page":"996-1005","source":"Crossref","is-referenced-by-count":0,"title":["The ImproveCareNow registry: Prediction of 2\u2010year nonremission in pediatric ulcerative colitis"],"prefix":"10.1002","volume":"82","author":[{"given":"Jonathan Van","family":"Hecke","sequence":"first","affiliation":[{"name":"Geneeskunde en Farmacie Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-9564","authenticated-orcid":false,"given":"Gigi","family":"Veereman","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Huysentruyt","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Wauters","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Adler","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center University of Michigan Ann Arbor Michigan USA"},{"name":"Division of Pediatric Gastroenterology Michigan Medicine Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehzad","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boonshoft School of Medicine Wright State University, and Dayton Children's Hospital Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth De","family":"Greef","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ImproveCareNow Pediatric IBD Learning Health System","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70096"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70097"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa245"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20928.1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.634739"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21394"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.029"},{"key":"e_1_2_9_13_1","unstructured":"Centers for Disease Control and Prevention NCfHS. 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