{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:10:33Z","timestamp":1778152233190,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Perianal abscesses (PA) and fistulas\u2010in\u2010ano (FIA) are frequently diagnosed in children and may be presenting symptoms of Crohn's disease (CD). The association between age at presentation of PA\/FIA and the risk of subsequent CD development is largely unknown. Aim of this study was to investigate the association between PA\/FIA and risk for CD development, stratified by age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective multicenter study children between 2 and 18 years presenting with PA\/FIA, were included. Patient characteristics, biochemical data, and data on CD development were collected. The risk of developing IBD was stratified by age in three subgroups (&lt;6, 6\u201312, and 12\u201318 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and fifty\u2010two children with PA\/FIA were included (78% male; median age 11.1 years; interquartile range [IQR]: 8.0), of whom 32 (21.1%) were diagnosed with CD. Children aged 12\u201318 years (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u200923; 32.4%) were more often diagnosed with CD compared to the subgroup 6\u201312 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098; 15.1%) odds ratio (OR) 2.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and the subgroup 2\u20136 years (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u20091; 3.6%; OR 14.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Recurrent PA\/FIA (OR 3.20;\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.005) and typical inflammatory bowel disease (IBD)\u2010associated symptoms (OR 4.85;\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001) were significantly associated with CD development. Median value of elevated fecal calprotectin (FCP) was significantly higher in the CD group (1212\u2009\u00b5g\/g) than in the non\u2010CD group (22.5\u2009\u00b5g\/g;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The overall risk of developing CD in children presenting with PA\/FIA was 21%, this risk was age dependent. Our findings emphasize the need for high awareness by physicians in children presenting with PA\/FIA for the development of CD, also in the years following first presentation, particularly when aged \u22656 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70373","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:54:21Z","timestamp":1772992461000},"page":"1226-1232","source":"Crossref","is-referenced-by-count":1,"title":["Risk of Crohn's disease in children presenting with perianal abscess and fistula increases with age: A multicenter study"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-2710","authenticated-orcid":false,"given":"Mari\u00eblle","family":"Roskam","sequence":"first","affiliation":[{"name":"Department of Pediatrics Emma Children's Hospital, Amsterdam Medical Center Meibergdreef 9 Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Dierikx","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital, Amsterdam UMC VU University Medical Center Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Hulsmann","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital, Amsterdam UMC VU University Medical Center Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Lemmen","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital, Amsterdam UMC VU University Medical Center Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Leijdekkers","sequence":"additional","affiliation":[{"name":"Department of Surgery OLVG Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Luttikhold","sequence":"additional","affiliation":[{"name":"Department of Surgery Amstelland Hospital Amstelveen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Garssen","sequence":"additional","affiliation":[{"name":"Department of Surgery Amstelland Hospital Amstelveen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich","family":"Dunker","sequence":"additional","affiliation":[{"name":"Department of Surgery Noordwest Ziekenhuisgroep Alkmaar The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarmila","family":"van der Bilt","sequence":"additional","affiliation":[{"name":"Department of Surgery Flevoziekenhuis Almere The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Emma Children's Hospital, Amsterdam UMC, Amsterdam Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"van Heurn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Emma Children's Hospital, Amsterdam UMC, Amsterdam Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanne","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Amsterdam UMC, VU Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roel","family":"Bakx","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Emma Children's Hospital, Amsterdam UMC, Amsterdam Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"de Meij","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Emma Children's Hospital, Amsterdam UMC, Amsterdam Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90587-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2006.10.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.06.2009.2025"},{"issue":"39","key":"e_1_2_8_5_1","article-title":"Perianal fistulae and abscesses in children: consider Crohn's disease","volume":"157","author":"Coblijn UK","year":"2013","journal-title":"Ned Tijdschr 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