{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:10:29Z","timestamp":1778152229502,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated whether serum biomarkers reflecting intestinal membrane integrity will serve as predictors for post\u2010operative feeding intolerance (FI) in patients with congenital heart disease (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled infants \u2265 35 weeks gestational age, aged 0\u20106 months, with complex CHD undergoing palliation surgery. After surgery, blood samples were obtained prior to the initiation of enteral feeds, at 7 and 14\u2010days post feeding initiation, and at times of symptoms of FI and\/or necrotizing enterocolitis (NEC). Plasma biomarkers of tight junction integrity (claudin\u20103), villus injury (I\u2010FABP), and clinical outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four infants were included in the analysis, and twelve of those had FI and\/or symptoms of NEC. Patients in the FI group had higher peak claudin\u20103 than controls (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Claudin\u20103 was overall higher during 28 days after surgery in patients with FI. Pre\u2010feeding I\u2010FABP levels were higher for the FI group vs. control group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006) but did not rise afterward. Higher cardiopulmonary bypass time and maximal lactate was associated with FI. Weight for length at discharge was significantly lower in patients with FI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We suggest that, when measured sequentially, plasma levels of I\u2010FABP and claudin\u20103 may help to predict children with CHD at risk of feeding intolerance post cardiac surgery. If further validated in larger cohort, these biomarkers may aid in optimizing feeding protocols aimed at reducing sequelae such as NEC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70377","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:57:19Z","timestamp":1771235839000},"page":"1309-1315","source":"Crossref","is-referenced-by-count":0,"title":["Biomarkers for feeding intolerance in infants with complex heart defects undergoing palliation surgery"],"prefix":"10.1002","volume":"82","author":[{"given":"Katarzyna","family":"Bigaj","sequence":"first","affiliation":[{"name":"Department of Pediatrics Gastroenterology, The Children's Hospital at Montefiore Einstein Bronx New York USA"},{"name":"Department of Pediatrics Gastroenterology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth) Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro Coronado","family":"Munoz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Critical Care, The Children's Hospital at Montefiore Einstein, Bronx Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-9254","authenticated-orcid":false,"given":"Yuying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastroenterology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth) Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-6564","authenticated-orcid":false,"given":"Supriya","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastroenterology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth) Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Pediatric Gastroenterology\u2013PICU\u2013Cardiac Surgery Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000402"},{"key":"e_1_2_9_4_1","first-page":"196","article-title":"Feeding dysfunctions and failure to thrive in neonates with congenital heart diseases","volume":"40","author":"Mangili G","year":"2018","journal-title":"Pediatr Med 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the incidence of necrotizing enterocolitis in neonates with hypoplastic left heart syndrome with the introduction of an enteral feed protocol","volume":"11","author":"Castillo SL","year":"2010","journal-title":"Pediatr Crit Care Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34975-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000256"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.071571"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111000154X"}],"container-title":["Journal of Pediatric Gastroenterology and 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