{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:36:00Z","timestamp":1782545760650,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Tofacitinib is a selective Janus kinase (JAK\u20101) inhibitor approved for the treatment of ulcerative colitis (UC) in adults. Data is limited in the pediatric population. The aim of this study was to evaluate the efficacy of tofacitinib in pediatric inflammatory bowel disease (IBD). The primary aim was to assess clinical response (categorical improvement in disease activity from baseline) after induction (8\u201312 weeks). The secondary aims were to assess effectiveness of tofacitinib in achieving corticosteroid\u2010free remission and biochemical response and overall safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective multicenter study of pediatric patients with IBD at eight centers across the United States between 2018 and 2023. We collected demographic data, disease classification, prior biologic medication use, laboratory and clinical disease activity, corticosteroid use, adverse events and side effects, and surgical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010seven patients were included in this study. Eighteen patients (52.9%) achieved a clinical response within 8\u201312 weeks, which increased to 20 (58.8%) by 20\u201328 weeks. Corticosteroid\u2010free remission was achieved by 14 patients (41.2%) by 8\u201312 weeks, followed by 16 patients (47.1%) at 20\u201328 weeks. Improvement in albumin and C\u2010reactive protein (CRP) occurred as early as 8\u201312 weeks. Surgical rate was 10.5% (4\/38 patients). Infection was a common adverse effect reported with the use of tofacitinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is one of the largest studies evaluating the use of tofacitinib in pediatric IBD in the United States. Our results demonstrate that tofacitinib is an effective treatment for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70381","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:22:43Z","timestamp":1771233763000},"page":"1218-1225","source":"Crossref","is-referenced-by-count":1,"title":["Multicenter experience using tofacitinib for treatment of refractory pediatric inflammatory bowel diseases in the United States"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-6376","authenticated-orcid":false,"given":"Denise D.","family":"Young","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Clinical Research Center University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallory","family":"Chavannes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital Los Angeles Division of Gastroenterology, Hepatology and Nutrition Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Dotson","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Tung","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition University of Oklahoma Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Crawford","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"McGreal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Moses","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford Medicine Children's Hospital Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.10.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058037"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otaa063"},{"issue":"2","key":"e_1_2_8_7_1","article-title":"The medical management of paediatric Crohn's disease: an ECCO\u2010ESPGHAN guideline update","volume":"15","author":"Rheenen PF","year":"2021","journal-title":"J Crohns 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