{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:50:58Z","timestamp":1783626658020,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pediatric patients with in\u2010remission inflammatory bowel disease (IBD) often report persistent gastrointestinal symptoms, suggesting a potential overlap with disorders of gut\u2013brain\u2010interaction (DGBIs). While DGBIs affect up to 40% of the general population, their prevalence in quiescent IBD children remains limited. We aimed to evaluate the prevalence and distribution of DGBIs, based on Rome\u2010IV criteria, in children with quiescent IBD compared to healthy controls, identifying demographic, clinical and therapeutic factors associated with DGBIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, prospective, controlled study, in\u2010remission IBD pediatric patients and healthy controls were enrolled completing the Rome IV\u2010Questionnaire. IBD\u2010remission was defined by pediatric ulcerative colitis activity index (PUCAI)\/pediatric Crohn's disease activity index scores\u2009&lt;\u200910, normal inflammatory markers and recent endoscopic mucosal healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one pediatric patients with IBD in remission and 179 healthy controls were enrolled. DGBIs were found in 41.46% of IBD\u2010patients versus 27.93% of controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.089). Functional Dyspepsia was significantly more prevalent in IBD patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while irritable bowel syndrome was more frequent among controls, though not significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.466). No differences in DGBI prevalence emerged between Crohn's disease and ulcerative colitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.54). At the multivariate analysis, psychological comorbidities (odds ratio [OR] 40.767,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and low weight (0.953,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001) were significantly associated with DGBIs. Notably, 5\u2010aminosalicylic\u2010acid (ASA) administration was associated with reduced DGBIs likelihood (OR 0.139,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our cohort, the overall DGBIs prevalence was numerically but not significantly higher in quiescent\u2010IBD patients compared to controls, while upper gastrointestinal DGBIs were significantly more frequent in IBD patients. Psychological and nutritional factors emerged as strong predictors of DGBIs, while 5\u2010ASA may be associated with lower likelihood of DGBIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70386","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:32:51Z","timestamp":1773005571000},"page":"1171-1177","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of disorders of gut\u2013brain\u2010interaction in pediatric patients with in\u2010remission inflammatory bowel disease: An Italian multicenter study"],"prefix":"10.1002","volume":"82","author":[{"given":"Giovanna","family":"Quatrale","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccolo\u2019","family":"Chirico","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Colecchia","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Stella","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Proli","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminia","family":"Romeo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit, Bambino Gesu\u0300 Children's Hospital, IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit, Bambino Gesu\u0300 Children's Hospital, IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Pensabene","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Pediatric Unit Magna Graecia University Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"},{"name":"Gastroenterology and Endoscopy Unit, Department of Pediatric Specialties Santobono Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Scaldaferri","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-8710","authenticated-orcid":false,"given":"Valentina","family":"Giorgio","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario \u201cA. 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