{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:10:34Z","timestamp":1778152234339,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Monitoring for\n                      <jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic>\n                      \u2010eradication is important, since symptom improvement does not indicate treatment success. Using EuroPedHp Registry data, we investigated characteristics of children missing monitoring visits after prescribed therapy, compliance effect on eradication, and factors associated with loss to follow\u2010up and low compliance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between 2017 and 2020, 30 paediatric hospitals from 17 European countries reported 1605 children with biopsy\u2010proven\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010infection. Children with prescribed therapy were analysed. Risk factors for loss to follow\u2010up or low compliance (taking \u226490% of prescribed medications) were identified applying multivariable logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1263 infected children with prescribed therapy, 390 (31%) were lost to follow\u2010up. Risk factors for loss to follow\u2010up included nausea\/dyspepsia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) or gastrointestinal bleeding (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) as indication for endoscopy, living in Israel or T\u00fcrkiye (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002), and having no antibiotic susceptibility result (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Risk decreased with living in Southern Europe (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), migration background (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.052), and probiotic use during therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Low compliance, reported in 69\/831 (8%) children with follow\u2010up data, was associated with vomiting (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), peptic ulcers or erosions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), living in EasternEurope (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), Israel or T\u00fcrkiye (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008), and any adverse event during therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0009). First\u2010line tailored triple therapy (TTT) for 14 days (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009480) was successful in 92% with excellent versus 61% with low compliance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). After \u22651 failed therapies (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200960), TTT was successful in 71% with high versus 13% with low compliance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The registry data identified several factors associated with non\u2010adherence to medication and monitoring visits. Improving information to patient\/caregiver may increase adherence, care and treatment success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70387","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:51:25Z","timestamp":1772963485000},"page":"1178-1192","source":"Crossref","is-referenced-by-count":0,"title":["Factors related to loss to follow\u2010up and low compliance in\n                    <i>Helicobacter pylori<\/i>\n                    \u2010infected children: The EuroPedHp Registry"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-9551","authenticated-orcid":false,"given":"Thu Giang","family":"Le Thi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dr. von Hauner Children's Hospital LMU University Hospital Munich Munich Germany"},{"name":"Stiftung Kindergesundheit, c\/o Dr. von Hauner Children's Hospital LMU University Hospital Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kallirroi","family":"Kotilea","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles, H\u00f4pital Universitaire des Enfants Reine Fabiola Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Cabral","sequence":"additional","affiliation":[{"name":"Child and Adolescent Centre, CUF Tejo Hospital Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Kori","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Kaplan Medical Centre Rehovot Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luz","family":"Cilleruelo","sequence":"additional","affiliation":[{"name":"Pediatrics Department. Gastroenterology Unit University Hospital Puerta de Hierro Majadahonda Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tavares","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Department Division of Pediatrics, Centro Materno Infantil do Norte, ICBAS \u2010 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Barrio","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Gastroenterology Unit University Hospital, Fuenlabrada Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaidotas","family":"Urbonas","sequence":"additional","affiliation":[{"name":"Clinic of Children's Diseases of Vilnius University Faculty of Medicine Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matja\u017e","family":"Homan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition University Children's Hospital, Faculty of Medicine, University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zrinjka","family":"Misak","sequence":"additional","affiliation":[{"name":"Referral Centre for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb University of Zagreb School of Medicine Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Kalach","sequence":"additional","affiliation":[{"name":"Saint Antoine Pediatric Clinic, Saint Vincent de Paul Hospital, Groupement des H\u00f4pitaux de l'Institut Catholique de Lille (GHICL) Catholic University Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Urruzuno","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit. Hospital 12 de Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Klemenak","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Unit, Department of Paediatrics University Medical Centre Maribor Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Krahl","sequence":"additional","affiliation":[{"name":"Darmst\u00e4dter Kinderkliniken Prinzessin Margaret Darmstadt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Chiaro","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit, Institute Giannina Gaslini Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Sykora","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Charles University in Prague, Faculty of Medicine in Pilsen  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem Korkut","family":"Ugras","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology Hepatology and Nutrition Yeditepe University Faculty of Medicine \u0130stanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"de Laffolie","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Centre of Child and Adolescent Medicine Justus\u2010Liebig\u2010University Gie\u00dfen Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erasmo","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"First Department of Paediatrics 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