{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:10:31Z","timestamp":1778152231798,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Children with inflammatory bowel disease (IBD) have an increased risk of developing kidney disorders, which may cause significant kidney function impairment (SKI) or lead to chronic kidney disease (CKD). In this study we aimed to provide insights in causes and diagnoses of SKI cases and to provide recommendations for pediatric gastroenterologists for children with IBD and SKI.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cases of SKI in children with IBD (<19 years) were collected from the international, prospective PIBD\u2010SETQuality Safety Registry. A monthly survey was sent to participating pediatric gastroenterologists to report cases of SKI (defined as an estimated glomerular filtration rate (eGFR)\u2009<\u200960\u2009mL\/min\/1.73m\n 2<\/jats:sup>\n ). Additionally, a panel consisting of 16 members (including experts in pediatric IBD and nephrology) rated the most likely cause of the cases and formulated recommendations for screening, follow\u2010up and referral for children with IBD and SKI.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between November 1, 2016 and December 31, 2023, 42 cases of SKI were eligible for analysis. Tubulo\u2010interstitial nephritis (TIN) was the most common diagnosis (\n n<\/jats:italic>\n \u2009=\u200915). Sixteen (38%) cases were confirmed with renal biopsy (10 cases of TIN). Twelve patients developed CKD. IBD medication was the most frequently reported cause (\n n<\/jats:italic>\n \u2009=\u200915), however, there was low concordance between panelists about the most likely etiology (Fleiss' kappa 0.143 and 0.102).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This is the first prospective study to report cases of SKI in children with IBD. SKI may lead to CKD. Confirming the etiology of the SKI proved to be very challenging. The study provides recommendations for screening and follow\u2010up of SKI in children with IBD.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n NCT03571373, date of registration: June 27, 2018, URL:\n https:\/\/clinicaltrials.gov\/study\/NCT03571373<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jpn3.70391","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:41:31Z","timestamp":1773200491000},"page":"1251-1260","source":"Crossref","is-referenced-by-count":0,"title":["Significant kidney impairment in pediatric inflammatory bowel disease and practice points for pediatric gastroenterologists"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-7241","authenticated-orcid":false,"given":"Stephanie A.","family":"Vuijk","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Erasmus Medical Centre \u2010 Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renz C. W.","family":"Klomberg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Erasmus Medical Centre \u2010 Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schwerd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr von Hauner Children's Hospital University Hospital, LMU Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Centre, The Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9amus","family":"Hussey","sequence":"additional","affiliation":[{"name":"DOCHAS Group, Children's Health Ireland Royal College of Surgeons of Ireland and University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology & Nutrition, Department of Pediatrics University of Alberta Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter","family":"Malmborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Protima","family":"Deb","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Royal London Children's Hospital, Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margreet","family":"Wessels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Mouratidou","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"van Biervliet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ghent University Hospital Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Friedt","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Neonatology and Pediatric Cardiology University Children's Hospital D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie","family":"Minson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Royal London Children's Hospital Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke H. 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